- Basic information
- CohesinDB ID: CDBP00418347
- Locus: chr21-36171056-36173134
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Data sourse: ENCSR230ZWH, GSE67783, GSE86191, GSE98367, GSE206145-NatGen2015, ENCSR153HNT
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Cell type: Fibroblast, HCT-116, K-562, Liver, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 50%,
"7_Enh": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, PAX7, FOXO1, POU2F2, CHD8, SMC1A, CEBPA, ZNF263, ZFX, XBP1, ZNF317, WT1, ZBTB48, STAT1, FOXF1, MEF2C, PBX2, SMARCC1, TBP, ERG, YY1, RELA, CREBBP, NEUROD1, RUNX2, SP140, GRHL3, SOX11, RXRA, OTX2, CBFB, GABPA, MECOM, MAX, SPIB, GATA1, NRIP1, DNMT3B, VDR, NCOA3, NR2F2, KMT2A, ETV1, NR2F1, NEUROG2, ZNF3, ESR1, OCA2, TP53, NCOA1, CTCF, JUN, SPI1, EP300, SP1, BHLHE40, PAX3-FOXO1, NR4A1, RXR, GATA2, FLI1, NCOR1, MXI1, RNF2, BRD4, MAZ, SMC3, STAG1, TFAP2C
- Target gene symbol (double-evidenced CRMs): CHAF1B,DOP1B,MORC3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 7
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000142197,
ENSG00000159256,
ENSG00000159259,
- Related loop:
chr21:36075000-36100000~~chr21:36175000-36200000,
chr21:36150000-36175000~~chr21:36300000-36325000,
chr21:36150000-36175000~~chr21:36325000-36350000,
chr21:36150000-36175000~~chr21:36375000-36400000,
chr21:36150000-36175000~~chr21:39175000-39200000,
chr21:36150000-36175000~~chr21:46175000-46200000,
chr21:36175000-36200000~~chr21:36350000-36375000,
chr21:36175000-36200000~~chr21:36575000-36600000,