- Basic information
- CohesinDB ID: CDBP00418348
- Locus: chr21-36173521-36174893
-
Data sourse: ENCSR230ZWH, ENCSR000BKV, GSE67783, ENCSR000BSB, GSE72082, GSE86191, GSE98367, ENCSR879KXD, GSE206145-NatGen2015, ENCSR000BMY, ENCSR153HNT, GSE120943, GSE103477, GSE131606, GSE50893, GSE126755, ENCSR917QNE
-
Cell type: MCF-7, GM2630, MDM, Fibroblast, HCT-116, Monocytes, GM2610, GM19240, GM12878, GM2588, GM12891, K-562, Liver, Neutrophil, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.822
- Subunit: SA1,Rad21,SMC1
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 45%,
"15_Quies": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: UBTF, LYL1, THAP1, RUNX3, MECOM, MAF, JMJD1C, ELF1, BCLAF1, TRIM28, LMO2, ESR1, JUN, CTCF, TCF12, KLF1, E4F1, ARID5B, LMO1, E2F6, ZNF175, RBPJ, EED, POU2F2, CDK7, RUNX1T1, ZBTB48, STAT1, ERG, MYC, RAD21, GABPA, NFE2, RCOR1, VDR, CEBPB, STAT5B, KMT2A, ZBTB11, GABPB1, SPI1, GATA2, HCFC1, NR2C2, ATF1, RUNX1, MAFG, SMC1A, CBX1, CEBPA, ZFX, ZBTB2, ZNF384, NOTCH1, ZEB2, NR2C1, SUPT5H, CDK8, MYB, C11orf30, L3MBTL2, EVI1, BCL11A, SP1, NR4A1, PHIP, TCF3, TRP47, CBX3, CREM, GTF2B, MEF2C, KDM1A, YY1, RELA, ZFP36, GATA3, BATF, MGA, TAL1, MAX, GATA1, BCL11B, GFI1B, NR2F2, NR2F1, TBX21, TAF1, ZBTB16, ZBTB40, HSF1, RNF2, BRD4, JUND, ZNF316
- Target gene symbol (double-evidenced CRMs): MORC3,DOP1B,CHAF1B
- Function elements
- Human SNPs: Insulin-like_growth_factor_1_levels
- Number of somatic mutations (coding): 7
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000142197,
ENSG00000159256,
ENSG00000159259,
- Related loop:
chr21:36075000-36100000~~chr21:36175000-36200000,
chr21:36150000-36175000~~chr21:36300000-36325000,
chr21:36150000-36175000~~chr21:36325000-36350000,
chr21:36150000-36175000~~chr21:36375000-36400000,
chr21:36150000-36175000~~chr21:39175000-39200000,
chr21:36150000-36175000~~chr21:46175000-46200000,
chr21:36175000-36200000~~chr21:36350000-36375000,
chr21:36175000-36200000~~chr21:36575000-36600000,