- Basic information
- CohesinDB ID: CDBP00418353
- Locus: chr21-36180358-36184886
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Data sourse: ENCSR230ZWH, GSE72082, GSE132649, GSE111537, GSE25021, ENCSR917QNE, GSE93080, GSE67783, GSE86191, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE98367, GSE206145, GSE62063, ENCSR000BTQ, GSE111913, ENCSR153HNT, ENCSR000EDE, GSE83726, GSE126755, ENCSR000ECS
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Cell type: MCF-7, RPE, T-47D, Fibroblast, HCT-116, Monocytes, RH4, GM12878, OCI-AML-3, HeLa-S3, RT-112, K-562, Liver, Neutrophil, HSPC, Macrophage, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 7% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.811
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 49%,
"15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: WT1, BCOR, ZFX, DDX5
- Target gene symbol (double-evidenced CRMs): MORC3,CBR1,SETD4,DOP1B
- Function elements
- Human SNPs: Low_density_lipoprotein_cholesterol_levels
- Number of somatic mutations (coding): 20
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000185917,
ENSG00000159228,
ENSG00000142197,
ENSG00000159256,
- Related loop:
chr21:36075000-36100000~~chr21:36175000-36200000,
chr21:36152248-36154241~~chr21:36187568-36189319,
chr21:36175000-36200000~~chr21:36350000-36375000,
chr21:36175000-36200000~~chr21:36575000-36600000,
chr21:36181050-36182274~~chr21:36329784-36332238,
chr21:36187405-36189351~~chr21:36208897-36210863,
chr21:36187568-36189319~~chr21:36208696-36210781,