- Basic information
- CohesinDB ID: CDBP00418356
- Locus: chr21-36192532-36196146
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Data sourse: ENCSR000BTQ, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE98367, GSE76893, ENCSR879KXD, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE68388, ENCSR703TNG, GSE25021, GSE165895
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Cell type: MCF-7, Macrophage, RPE, Fibroblast, HCT-116, K-562, HSPC, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: NIPBL,SA1,Rad21,SMC1,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 56%,
"15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, ZSCAN5C, FOXA1, ZFP64, WDHD1, ZNF189, SMARCE1, TP63, TEAD1, TRIM28, ELF1, ETV1, ZNF217, ESR1, ZNF561, JUN, TCF12, CTCF, BAF155, EP300, MNT, DPF2, SOX4, MED12, E2F1, ZNF528, TEAD4, TFAP2C, GLIS1, CHD8, POU5F1, ZNF263, KDM4C, CTBP1, ZBTB17, HNF4G, ERG, ZBTB8A, ZNF341, MYC, SMARCA4, RAD21, NKX2-1, GABPA, NKX3-1, RCOR1, ZNF750, ESRRA, CEBPB, NR3C1, CREB1, BPTF, GRHL2, TRPS1, ZHX2, SPI1, HDAC2, GATA2, GATAD2B, NCOA2, RUNX1, CBX1, SMC1A, SIN3A, ZFX, AFF4, SMAD3, CBX8, SMARCC1, CREBBP, ZXDC, ZNF35, RUNX2, ZSCAN30, OSR2, GR, PBX4, ARNT, NFIB, FOXM1, FOS, MED1, ZNF680, SCRT2, PIAS1, ZNF41, NCOA1, EVI1, TBX5, MAFK, NIPBL, TFAP2A, NKX2-5, REST, ARID1A, ASH2L, CTBP2, PHIP, MBD2, SMC3, STAG1, PAX7, FOXA2, ZSCAN16, WT1, MAFF, ZNF574, HOXB13, RELA, NEUROD1, ZIC2, HIF1A, GATA3, ZNF519, MAX, NRIP1, ZNF143, MTA1, TLE3, KLF4, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, ZBTB6, BRD2, PAX3-FOXO1, AR, TAF1, ZNF579, YAP1, EGLN2, RNF2, BRD4, JUND, SCRT1, MAZ, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): DOP1B,MORC3,SETD4,CBR1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 11
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000185917,
ENSG00000159228,
ENSG00000142197,
ENSG00000159256,
- Related loop:
chr21:36050000-36075000~~chr21:36200000-36225000,
chr21:36075000-36100000~~chr21:36175000-36200000,
chr21:36152248-36154241~~chr21:36187568-36189319,
chr21:36175000-36200000~~chr21:36350000-36375000,
chr21:36175000-36200000~~chr21:36575000-36600000,
chr21:36187405-36189351~~chr21:36208897-36210863,
chr21:36187568-36189319~~chr21:36208696-36210781,
chr21:36200000-36225000~~chr21:36325000-36350000,
chr21:36200000-36225000~~chr21:36350000-36375000,
chr21:36200000-36225000~~chr21:36375000-36400000,