- Basic information
- CohesinDB ID: CDBP00418357
- Locus: chr21-36196672-36199361
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Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE67783, GSE72082, GSE86191, GSE98367, ENCSR153HNT, ENCSR703TNG, GSE25021, ENCSR917QNE
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Cell type: MCF-7, HCT-116, K-562, Liver, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: Mau2,SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 49%,
"15_Quies": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, PGR, SMC1A, PPARG, FOXA2, NKX2-2, CHD8, ZNF263, POU2F2, ZFX, XBP1, WT1, FOXA1, ZNF770, CBX8, RELA, JUNB, RUNX2, GATA4, THAP1, KDM4A, ZFP36, HIF1A, GRHL3, GABPA, MAFB, GATA1, ZNF143, RCOR1, DNMT3B, CDK8, TEAD3, TEAD1, ZMYM3, STAG1, ESR1, OCA2, MYOD1, JUN, CTCF, SPI1, AR, GATA6, GATA2, RBAK, BRD4, ZNF766, PDX1
- Target gene symbol (double-evidenced CRMs): CBR1,MORC3,SETD4,DOP1B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 69
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000185917,
ENSG00000159228,
ENSG00000142197,
ENSG00000159256,
- Related loop:
chr21:36050000-36075000~~chr21:36200000-36225000,
chr21:36075000-36100000~~chr21:36175000-36200000,
chr21:36175000-36200000~~chr21:36350000-36375000,
chr21:36175000-36200000~~chr21:36575000-36600000,
chr21:36200000-36225000~~chr21:36325000-36350000,
chr21:36200000-36225000~~chr21:36350000-36375000,
chr21:36200000-36225000~~chr21:36375000-36400000,