Deatailed information for cohesin site CDBP00418358

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  • Basic information
  • CohesinDB ID: CDBP00418358
  • Locus: chr21-36199941-36200843
  • Data sourse: ENCSR230ZWH, GSE67783, GSE86191, GSE98367, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE111537, GSE126755
  • Cell type: RPE, Fibroblast, HCT-116, Monocytes, OCI-AML-3, K-562, Liver, Neutrophil, HSPC, Macrophage
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 3% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.889
  • Subunit: SA1,Rad21,SMC1,SA2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 92% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 44%, "4_Tx": 26%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: NFIA, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB44, IKZF3, PAX5, TEAD1, ZNF121, SOX5, DEK, ZNF528, KMT2B, GATAD2A, POU5F1, TOP2A, CTBP1, STAT1, ZNF134, SAP130, ERG, PAX6, SMARCA4, ZNF398, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, TBX3, SP5, SMARCC1, PRDM10, ZNF549, ATF2, SMARCB1, PIAS1, NR1H2, C11orf30, IKZF5, MBD2, ELL2, ETV4, CBX3, CREM, CHD2, PAF1, ZSCAN16, WT1, MEF2C, JUNB, BATF, KLF4, ZFP69B, ZBTB6, EGR2, ELF3, ARID4B, EGLN2, ZNF366, HSF1, ZBTB26, SCRT1, FOSL1, ZNF660, XBP1, ATF3, THRB, ZFP64, RUNX3, TP63, MITF, BACH2, JMJD1C, ELF1, SNAI2, CTCF, JUN, MNT, DPF2, IRF4, ZNF423, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZSCAN21, ZNF317, ZBTB48, ZBTB17, MTA2, DDX5, NBN, ONECUT1, TSHZ1, HOMEZ, RXRA, NKX3-1, MIER3, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, KLF8, GRHL2, NFIL3, THAP11, SOX13, AFF4, POU4F2, ZNF770, ZNF18, SP3, DAXX, ARNT, ZNF48, ZEB2, HMBOX1, PBX3, MAFB, ZNF10, ETV6, HMGXB4, TEAD3, USF1, SP1, BCL11A, ZNF479, ASH2L, PRDM6, SMC3, STAG1, MLLT1, ZNF394, TRP47, EBF1, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, GATA3, NRIP1, AGO2, ZNF768, TP53, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, EGR1, RNF2, BRD4, JUND, CUX1, ZSCAN23, PGR, PATZ1, TFAP4, CHD7, MXD4, ZNF189, SMARCE1, KLF6, ESR1, SOX4, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZNF778, ZSCAN5A, ELK4, ERG2, SP4, TBP, HNF4G, HOXC5, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, ZNF652, SPI1, HDAC2, INTS13, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, ZNF35, ZNF384, CREBBP, SMAD4, CDK8, ZEB1, ZMYM3, SUPT16H, ZNF22, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, FOXP1, ZNF816, PPARG, ZNF692, ZNF30, ZNF574, TCF7, RELA, TARDBP, MAX, TCF7L2, NEUROG2, KDM5B, MYOD1, AR, YAP1, ZNF324, AHR, DMAP1, FOSL2, HMG20A, ZSCAN5C, E2F7, SUZ12, ZFHX2, INSM2, NFIC, ZNF362, PRDM1, CDX2, ZNF629, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, RAD51, E2F1, TEAD4, FOXA3, ZNF175, EED, CHD8, MYCN, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, ZNF639, FEZF1, TFE3, HBP1, IRF1, ZGPAT, MRTFB, SMC1A, FIP1L1, ZFX, SMAD3, CBX8, RUNX2, CDK6, GATA4, OSR2, ZNF184, GR, PBX4, NRF1, FOS, MED1, CEBPD, MYB, SCRT2, VEZF1, ZNF3, SETDB1, NIPBL, PHIP, TCF3, SKI, FOXA2, ZNF600, MIER2, CDK9, HOXB13, YY1, SP140, HIF1A, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, BHLHE40, NFKBIZ, TAF1, ZBTB42, MYNN, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): SETD4,DOP1B,MORC3,CBR1,CHAF1B
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 44
  • Number of somatic mutations (non-coding): 22
  • Related genes and loops
  • Related gene: ENSG00000185917, ENSG00000159228, ENSG00000142197, ENSG00000159256, ENSG00000159259,
  • Related loop: chr21:36050000-36075000~~chr21:36200000-36225000, chr21:36075000-36100000~~chr21:36175000-36200000, chr21:36175000-36200000~~chr21:36350000-36375000, chr21:36175000-36200000~~chr21:36575000-36600000, chr21:36200000-36225000~~chr21:36325000-36350000, chr21:36200000-36225000~~chr21:36350000-36375000, chr21:36200000-36225000~~chr21:36375000-36400000,
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