- Basic information
- CohesinDB ID: CDBP00418360
- Locus: chr21-36204496-36205970
-
Data sourse: GSE206145-NatGen2015, GSE67783, GSE86191
-
Cell type: Fibroblast, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SA1,Rad21,SA2
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 63%,
"7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: NFIA, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB44, IKZF3, PAX5, TEAD1, ZNF121, SOX5, DEK, ZNF528, KMT2B, GATAD2A, POU5F1, TOP2A, CTBP1, STAT1, ZNF134, SAP130, ERG, PAX6, SMARCA4, ZNF398, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, TBX3, SP5, SMARCC1, PRDM10, ZNF549, ATF2, SMARCB1, PIAS1, NR1H2, C11orf30, IKZF5, MBD2, ELL2, ETV4, CBX3, CREM, CHD2, PAF1, ZSCAN16, WT1, MEF2C, JUNB, BATF, KLF4, ZFP69B, ZBTB6, EGR2, ELF3, ARID4B, EGLN2, ZNF366, HSF1, ZBTB26, SCRT1, FOSL1, ZNF660, XBP1, ATF3, THRB, ZFP64, RUNX3, TP63, MITF, BACH2, JMJD1C, ELF1, SNAI2, CTCF, JUN, MNT, DPF2, IRF4, ZNF423, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZSCAN21, ZNF317, ZBTB48, ZBTB17, MTA2, DDX5, NBN, ONECUT1, TSHZ1, HOMEZ, RXRA, NKX3-1, MIER3, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, KLF8, GRHL2, NFIL3, THAP11, SOX13, AFF4, POU4F2, ZNF770, ZNF18, SP3, DAXX, ARNT, ZNF48, ZEB2, HMBOX1, PBX3, MAFB, ZNF10, ETV6, HMGXB4, TEAD3, USF1, SP1, BCL11A, ZNF479, ASH2L, PRDM6, SMC3, STAG1, MLLT1, ZNF394, TRP47, EBF1, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, GATA3, NRIP1, AGO2, ZNF768, TP53, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, EGR1, RNF2, BRD4, JUND, CUX1, ZSCAN23, PGR, PATZ1, TFAP4, CHD7, MXD4, ZNF189, SMARCE1, KLF6, ESR1, SOX4, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZNF778, ZSCAN5A, ELK4, ERG2, SP4, TBP, HNF4G, HOXC5, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, ZNF652, SPI1, HDAC2, INTS13, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, ZNF35, ZNF384, CREBBP, SMAD4, CDK8, ZEB1, ZMYM3, SUPT16H, ZNF22, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, FOXP1, ZNF816, PPARG, ZNF692, ZNF30, ZNF574, TCF7, RELA, TARDBP, MAX, TCF7L2, NEUROG2, KDM5B, MYOD1, AR, YAP1, ZNF324, AHR, DMAP1, FOSL2, HMG20A, ZSCAN5C, E2F7, SUZ12, ZFHX2, INSM2, NFIC, ZNF362, PRDM1, CDX2, ZNF629, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, RAD51, E2F1, TEAD4, FOXA3, ZNF175, EED, CHD8, MYCN, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, ZNF639, FEZF1, TFE3, HBP1, IRF1, ZGPAT, MRTFB, SMC1A, FIP1L1, ZFX, SMAD3, CBX8, RUNX2, CDK6, GATA4, OSR2, ZNF184, GR, PBX4, NRF1, FOS, MED1, CEBPD, MYB, SCRT2, VEZF1, ZNF3, SETDB1, NIPBL, PHIP, TCF3, SKI, FOXA2, ZNF600, MIER2, CDK9, HOXB13, YY1, SP140, HIF1A, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, BHLHE40, NFKBIZ, TAF1, ZBTB42, MYNN, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): CBR1,SETD4,CHAF1B,MORC3,DOP1B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 9
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000185917,
ENSG00000159228,
ENSG00000142197,
ENSG00000159256,
ENSG00000159259,
- Related loop:
chr21:36050000-36075000~~chr21:36200000-36225000,
chr21:36075000-36100000~~chr21:36175000-36200000,
chr21:36140628-36142797~~chr21:36208896-36211059,
chr21:36140770-36142598~~chr21:36208928-36210883,
chr21:36140789-36142775~~chr21:36208898-36210957,
chr21:36140792-36142611~~chr21:36208845-36210808,
chr21:36140799-36142837~~chr21:36208339-36210839,
chr21:36140808-36142792~~chr21:36208893-36211062,
chr21:36140818-36142825~~chr21:36208180-36210735,
chr21:36140822-36142823~~chr21:36208825-36210883,
chr21:36140824-36142795~~chr21:36208849-36210862,
chr21:36140828-36142593~~chr21:36208784-36210767,
chr21:36140836-36142645~~chr21:36208979-36210847,
chr21:36140837-36142525~~chr21:36208955-36210590,
chr21:36140838-36142714~~chr21:36208696-36210781,
chr21:36140838-36142786~~chr21:36208808-36211018,
chr21:36140843-36142531~~chr21:36208942-36210568,
chr21:36140848-36142815~~chr21:36208865-36210865,
chr21:36140849-36142584~~chr21:36208920-36210789,
chr21:36140850-36142837~~chr21:36208890-36210845,
chr21:36140852-36142557~~chr21:36208778-36210979,
chr21:36140862-36142780~~chr21:36208188-36210796,
chr21:36140863-36142602~~chr21:36208770-36210834,
chr21:36140866-36142633~~chr21:36208896-36210832,
chr21:36140870-36142745~~chr21:36209005-36210744,
chr21:36140871-36142703~~chr21:36208897-36210863,
chr21:36152011-36154258~~chr21:36208885-36210840,
chr21:36152043-36154290~~chr21:36208880-36210854,
chr21:36152093-36154114~~chr21:36208893-36211062,
chr21:36152185-36154228~~chr21:36208896-36210870,
chr21:36152191-36154260~~chr21:36208896-36210832,
chr21:36152213-36154154~~chr21:36208928-36210883,
chr21:36152221-36154080~~chr21:36208180-36210735,
chr21:36152227-36154127~~chr21:36208825-36210883,
chr21:36152242-36154206~~chr21:36208896-36211059,
chr21:36152248-36154241~~chr21:36208696-36210781,
chr21:36152259-36154196~~chr21:36208897-36210863,
chr21:36152272-36154246~~chr21:36208777-36210982,
chr21:36152322-36154109~~chr21:36208843-36210788,
chr21:36152382-36154180~~chr21:36208778-36210979,
chr21:36152395-36154141~~chr21:36208770-36210834,
chr21:36152396-36154049~~chr21:36208182-36211280,
chr21:36152486-36154104~~chr21:36208903-36211039,
chr21:36152494-36154153~~chr21:36208813-36210759,
chr21:36152513-36154017~~chr21:36208784-36210767,
chr21:36155171-36156841~~chr21:36208778-36210979,
chr21:36155462-36156722~~chr21:36208903-36211039,
chr21:36155654-36157667~~chr21:36208890-36210845,
chr21:36175000-36200000~~chr21:36350000-36375000,
chr21:36175000-36200000~~chr21:36575000-36600000,
chr21:36187405-36189351~~chr21:36208897-36210863,
chr21:36187568-36189319~~chr21:36208696-36210781,
chr21:36200000-36225000~~chr21:36325000-36350000,
chr21:36200000-36225000~~chr21:36350000-36375000,
chr21:36200000-36225000~~chr21:36375000-36400000,
chr21:36208725-36210834~~chr21:36329820-36331841,
chr21:36208807-36210881~~chr21:36329776-36331875,
chr21:36208849-36210862~~chr21:36329821-36332549,
chr21:36208896-36211059~~chr21:36329784-36332238,
chr21:36208955-36210590~~chr21:36330185-36331807,
chr21:36209099-36210510~~chr21:36330219-36331784,
chr21:36209109-36210630~~chr21:36330220-36331778,
chr21:36209128-36210456~~chr21:36330409-36331736,