Deatailed information for cohesin site CDBP00418377

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  • Basic information
  • CohesinDB ID: CDBP00418377
  • Locus: chr21-36245119-36246670
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, ENCSR000FAD, GSE72082, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE131606, GSE25021, GSE115602, ENCSR000BTU, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE206145-NatGen2015, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE38411
  • Cell type: RH4, GM2610, GM19240, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, MB157, GM12878, GM12891, GM2588, SK-N-SH, RT-112, GM19099, HUES64, Macrophage, MCF-7, HCT-116, Hep-G2, GM19238, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 15% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.633
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 92% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): False
  • Chromatin annotation: "4_Tx": 45%, "5_TxWk": 28%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: PGR, MEIS2, XBP1, FOXA1, SUZ12, PBX2, UBTF, TFAP4, ATF3, NFIC, CBFB, SMARCE1, ELF1, ETV1, LMO2, ESR1, OCA2, ZNF217, CTCF, TCF12, JUN, BAF155, EP300, MNT, GATA6, DPF2, E2F6, TRIM24, E2F1, TEAD4, GTF2F1, PDX1, TFAP2C, NANOG, CHD8, POU2F2, ZSCAN5D, ZNF263, MYCN, RUNX1T1, POU5F1, KDM4C, CTBP1, ZBTB48, ZSCAN5A, ERG2, TBP, HNF4G, ERG, OGG1, MYC, EZH1, RAD21, GRHL3, RXRA, GABPA, STAT3, XRCC5, NKX3-1, PRDM14, DNMT3B, VDR, NR3C1, CREB1, EZH2, GRHL2, ZNF652, ZHX2, HDAC2, GATA2, FLI1, NCOA2, ETV5, RUNX1, SMC1A, BCL6, CBX1, SIN3A, ZFX, POU4F2, SMAD3, TET2, ERG3, ZBTB2, CREBBP, ZXDC, NRF1, ARNT, CHD1, CDK8, MED1, CSNK2A1, KDM6B, PIAS1, ZNF3, HIF2A, SP1, NIPBL, GSPT2, HNF4A, REST, ZBTB7A, ASH2L, CTBP2, MBD2, FOXP1, AATF, SMC3, STAG1, PAX7, TRP47, CBFA2T2, FOXA2, TBL1X, ZNF600, WT1, FOXF1, CDK9, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, SP140, ZFP36, HIF1A, GATA3, MAF1, MAX, NRIP1, ZNF143, AGO2, CBX2, KLF4, GFI1B, NR2F2, NCOA3, NR2F1, KDM5B, TP53, AR, RXR, HEXIM1, EGR1, TFIIIC, HSF1, RNF2, BRD4, JUND, MAZ, AHR
  • Target gene symbol (double-evidenced CRMs): MORC3,SMIM11A,CBR3,DOP1B
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 268
  • Number of somatic mutations (non-coding): 205
  • Related genes and loops
  • Related gene: ENSG00000205670, ENSG00000159231, ENSG00000142197, ENSG00000159256,
  • Related loop: chr21:34350000-34375000~~chr21:36225000-36250000, chr21:36125000-36150000~~chr21:36225000-36250000, chr21:36225000-36250000~~chr21:36325000-36350000, chr21:36245123-36246662~~chr21:36330384-36331754, chr21:36245246-36246544~~chr21:36329821-36332549, chr21:36250000-36275000~~chr21:36350000-36375000, chr21:36250000-36275000~~chr21:36375000-36400000, chr21:36250000-36275000~~chr21:36550000-36575000,
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