Deatailed information for cohesin site CDBP00418381

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  • Basic information
  • CohesinDB ID: CDBP00418381
  • Locus: chr21-36252668-36253134
  • Data sourse: GSE67783, ENCSR153HNT, GSE86191
  • Cell type: K-562, HCT-116, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 1% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.967
  • Subunit: SA1,Rad21
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: non-Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 89% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): False
  • Chromatin annotation: "5_TxWk": 49%, "4_Tx": 38%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, PGR, PLRG1, SMARCA2, HMG20A, LCORL, ZNF660, SOX2, XBP1, KDM4B, FOXA1, SUZ12, RXRB, PBX2, ZFHX2, HNRNPK, HDGF, ATF3, NFIC, INSM2, ZNF362, RUNX3, CHD7, ZBTB44, ZNF444, CBFB, MXD4, PAX5, ZNF467, ZNF629, MAF, TEAD1, TRIM28, BCLAF1, ETV1, SNAI2, ZNF121, LMO2, ESR1, RCOR2, OCA2, ZNF23, CTCF, TCF12, SND1, BAF155, ARID5B, EP300, LMO1, E4F1, SOX5, MNT, DPF2, IRF4, GLI4, ZNF407, RAD51, ZNF776, E2F1, TEAD4, FOXA3, GATAD2A, PDX1, TFAP2C, EED, RBPJ, GLIS1, YBX1, EHMT2, NANOG, POU2F2, CHD8, MYCN, ZNF263, CDK7, POU5F1, ZNF778, CTBP1, MTA2, ERF, ZBTB48, ZSCAN5A, ZBTB17, ZSCAN21, NONO, ZNF205, DDX5, NBN, ERG2, SP4, PHB2, ERG, ZBTB21, ASCL1, ETS1, MYC, SMARCA4, RAD21, DNMT1, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, NKX3-1, ZNF398, IKZF1, NR2F6, ZNF639, DACH1, NR3C1, ESRRA, CEBPB, KMT2A, CREB1, EZH2, ARHGAP35, BMPR1A, TRPS1, SPI1, MIXL1, HDAC2, GATA2, ZNF644, GATAD2B, SIX2, FLI1, HCFC1, ZNF785, SMARCA5, RELB, NFIL3, NCOA2, ZNF554, ETV5, SALL2, RUNX1, THAP11, SMC1A, BCL6, CEBPA, NKX2-2, ZNF707, HDAC1, SIN3A, ZFX, SOX13, ZNF747, ZNF473, ERG3, CBX8, NFXL1, TRIM22, ZNF549, PRDM10, SMARCC1, MEF2A, CREBBP, ZNF384, NOTCH1, RARA, ZNF35, ZBTB2, RUNX2, OSR2, GR, ZNF184, ZNF280C, ARNT, ZBTB10, ATF2, SMAD4, ZEB2, NR2C1, SUPT5H, CDK8, MED1, GMEB1, TEAD3, ZEB1, MYB, SCRT2, PIAS1, ZNF680, L3MBTL2, ZNF22, NIPBL, BCL11A, SP1, HNF4A, ARID2, ZNF479, ATF7, ASH2L, CTBP2, BCOR, MBD2, TCF3, FOXP1, PRDM6, SALL1, SMC3, NCOR2, MLLT1, STAG1, ETV4, ZNF239, CBFA2T2, MEF2B, PPARG, ZNF207, FOXA2, EBF1, CREM, ZNF316, E2F8, ZNF600, ZNF692, GTF2B, WT1, ZNF662, ZBTB33, MEF2C, TCF7, CDK9, HOXB13, KDM1A, YY1, RELA, TARDBP, NEUROD1, JUNB, ZNF148, ZNF521, ZNF282, ZFP36, HIF1A, TCF4, SKIL, BHLHE22, GATA3, OTX2, ZNF311, TAL1, MAX, SPIB, NRIP1, GATA1, ZNF143, MTA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF544, TCF7L2, NEUROG2, KDM5B, ZNF354C, PKNOX1, BCL6B, MYOD1, EGR2, PHOX2B, ELF3, KAT8, TBX21, ARID4B, AR, BHLHE40, TAF1, EGLN2, ZBTB42, EGR1, ZNF366, ZBTB26, RNF2, IKZF2, BRD4, JUND, NCOR1, MAZ, ZSCAN23, TBX2, ZNF24, AHR
  • Target gene symbol (double-evidenced CRMs): MORC3,CHAF1B,DOP1B
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 2
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000142197, ENSG00000159256, ENSG00000159259,
  • Related loop: chr21:34350000-34375000~~chr21:36225000-36250000, chr21:36125000-36150000~~chr21:36225000-36250000, chr21:36225000-36250000~~chr21:36325000-36350000, chr21:36250000-36275000~~chr21:36350000-36375000, chr21:36250000-36275000~~chr21:36375000-36400000, chr21:36250000-36275000~~chr21:36550000-36575000, chr21:36253261-36254421~~chr21:36319310-36321320,
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