- Basic information
- CohesinDB ID: CDBP00418384
- Locus: chr21-36260022-36261928
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE93080, GSE101921, ENCSR806UKK, GSE120943, GSE130135, ENCSR199XBQ, GSE94872, ENCSR000EEG, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE126755, ENCSR748MVX, ENCSR000ECS, ENCSR000BLD, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE72082, ENCSR501LQA, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, OCI-AML-3, Liver, HuCC-T1, H9-hESC, RPE, HMEC, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, HFFc6, GM18526, H1-hESC, GM18951, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GBM39, SK-N-SH, GM19239, RT-112, GM19193, THP-1, Macrophage, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, TC-71, Neutrophil, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 39% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.422
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
89% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"5_TxWk": 36%,
"1_TssA": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, CBX5, HMG20A, ZNF660, ZSCAN5C, HNF1A, PATZ1, FOXA1, RXRB, UBTF, HNRNPK, HDGF, NFIC, ZFP64, THAP1, CTCFL, RUNX3, PRDM1, IKZF3, ZNF189, SMARCE1, ZSCAN4, MZF1, MITF, ZNF467, CDC5L, JMJD1C, TEAD1, TRIM28, ZNF121, KLF6, RBM39, BCLAF1, RCOR2, ESR1, HNF1B, PITX3, USF2, CTCF, JUN, EP300, E4F1, BAF155, ZBTB20, MNT, LMO1, ARID5B, DPF2, TRIM24, IRF4, ZNF407, SOX6, RFX5, RAD51, SMC1, TEAD4, FOXA3, KMT2B, GATAD2A, EHMT2, RBPJ, PDX1, EED, GLIS1, POU2F2, CHD8, ZNF239, ZNF263, POU5F1, ID3, CDK7, CTBP1, ZSCAN21, ZBTB17, MTA2, ZBTB48, ZNF317, STAT1, SRF, SAP130, NBN, ARID3A, TBP, ERG, HOXC5, SMARCC2, MYC, ONECUT1, SMARCA4, ARID1B, RAD21, RXRA, NKX2-1, FOXK2, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, IKZF1, LEF1, MIER3, ZNF639, NFE2, RCOR1, NR2F6, NR3C1, CEBPB, KMT2A, CREB1, EZH2, FEZF1, EBF3, GABPB1, ZHX2, SPI1, TFE3, MIXL1, IRF1, PCBP1, HDAC2, GATA2, ZSCAN29, FLI1, HCFC1, ZGPAT, MXI1, SMARCA5, RELB, MRTFB, ZNF76, EP400, ZIM3, NFIL3, ATF1, RUNX1, THAP11, SMC1A, CBX1, HDAC1, LDB1, NKX2-2, BCL6, SIN3A, ZFX, AFF4, SMAD3, PCBP2, ZNF770, ERG3, TRIM22, PRDM10, IRF2, ZBTB2, ZNF35, NOTCH1, CREBBP, BRD9, RUNX2, ARNT, ATF2, ZEB2, ETV6, MAFB, NR2C1, SUPT5H, HMGXB4, FOS, ZNF10, CDK8, MED1, TEAD3, ZEB1, ZXDB, MYB, SCRT2, ZMYM3, NCOA1, L3MBTL2, SETDB1, KLF16, SP1, BCL11A, HNF4A, REST, ARID1A, ZBTB7A, RBM25, ATF7, ASH2L, AFF1, BCOR, FOXP1, PHIP, SMC3, ELL2, MLLT1, STAG2, STAG1, NFATC3, MEF2B, PPARG, FOXA2, CBX3, RBBP5, MTA3, PAF1, E2F8, ZNF600, ZNF692, MIER2, WT1, ZNF30, ZSCAN16, GTF2B, ZNF574, MEF2C, CDK9, ZNF580, HOXB13, ZNF318, KDM1A, YY1, ZNF502, RELA, TARDBP, NEUROD1, AHR, JUNB, TCF4, SKIL, HIF1A, OTX2, GATA3, BHLHE22, BATF, MGA, TAL1, MAX, SPIB, ZNF143, MTA1, GATA1, SP7, GFI1B, NR2F2, ZNF512, KDM5B, TP53, NFKB1, PHOX2B, BRD2, ELF3, KAT8, TBX21, NFKBIZ, ARID4B, AR, ZBTB40, ZNF324, EGLN2, ZNF366, RNF2, NCOR1, BRD4, SCRT1, ILF3, JUND, IKZF2, MAZ, CUX1, CLOCK, ZNF24, DMAP1
- Target gene symbol (double-evidenced CRMs): CHAF1B,DOP1B,MORC3
- Function elements
- Human SNPs: Menstruation_quality_of_life_impact_(joint_pain)
- Number of somatic mutations (coding): 19
- Number of somatic mutations (non-coding): 1
- Related genes and loops