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Basic information

CohesinDB ID: CDBP00418445

Locus: chr21-36400631-36402974

Data sourse: GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE62063, ENCSR153HNT, ENCSR703TNG

Cell type: MCF-7, HCT-116, K-562, HSPC, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: NIPBL,SA1,Rad21,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 49%, "4_Tx": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, POU2F2, NANOG, CEBPA, SIRT6, TBL1X, MYCN, ZNF263, ZFX, XBP1, ZBTB48, ZSCAN5A, STAT1, WT1, FOXA1, LEO1, YY1, ARNT, GABPA, SUPT5H, OCA2, BRD4, MAZ

Target gene symbol (double-evidenced CRMs): SMIM11A,SIM2,TTC3,CHAF1B,HLCS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 40

Number of somatic mutations (non-coding): 40

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159259, ENSG00000159263, ENSG00000159267, ENSG00000182670,

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Deatailed information for cohesin site CDBP00418445