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Basic information

CohesinDB ID: CDBP00418455

Locus: chr21-36424574-36425739

Data sourse: ENCSR000EFJ, GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE165895

Cell type: RPE, Fibroblast, HCT-116, IMR-90, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 41%, "5_TxWk": 40%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, SOX2, MEIS2, XBP1, PATZ1, FOXA1, SUZ12, PBX2, LEO1, ZFHX2, HDGF, ATF3, ZFP64, THAP1, CTCFL, RUNX3, CHD7, IKZF3, ZNF444, ZNF189, SMARCE1, MECOM, MITF, SFPQ, ZNF467, JMJD1C, ELF1, ZNF121, TRIM28, ETV1, RBM39, TEAD1, BCLAF1, NFE2L2, ESR1, LMO2, PITX3, USF2, ZNF561, CTCF, JUN, TCF12, EP300, E4F1, BAF155, MNT, LMO1, SOX5, DPF2, SOX4, E2F6, IRF4, SOX6, DEK, E2F1, SMC1, TEAD4, FOXA3, GATAD2A, GTF2F1, MLX, EED, TFAP2C, GLIS1, JARID2, POU2F2, NANOG, BRD1, ZSCAN5D, MYCN, POU5F1, ID3, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, MTA2, SRF, ZNF134, DDX5, ERG2, SP4, TBP, ERG, SMARCC2, ETS1, MYC, ZNF341, SMARCA4, EOMES, ARID1B, RAD21, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, PRDM14, IKZF1, RCOR1, NFE2, DNMT3B, NR3C1, ESRRA, SRSF3, CEBPB, CREB1, CCAR2, EZH2, FEZF1, EBF3, GABPB1, ZHX2, SPI1, TFE3, MIXL1, KLF17, HDAC2, GATA2, MXD3, FLI1, MXI1, SMARCA5, HCFC1R1, MRTFB, ZNF554, ATF1, ETV5, CC2D1A, PTBP1, RUNX1, SMC1A, CBX1, HDAC1, SIRT6, CEBPA, SIN3A, ZFX, SMAD3, ZNF654, ERG3, TET2, TRIM22, SMARCC1, IRF2, ZBTB2, CREBBP, RARA, NOTCH1, ZNF35, RUNX2, CDK6, GATA4, ZNF384, ZNF184, ARNT, TFDP1, ZNF48, CBFA2T3, ZNF10, SMARCB1, CDK8, HMGXB4, CHD1, SUPT5H, MED1, FOS, TEAD3, ZEB1, CEBPD, MYB, PIAS1, ZMYM3, ZNF3, KLF9, NCOA1, L3MBTL2, TBX5, EVI1, KLF16, RBM22, USF1, NIPBL, BCL11A, SP1, HNF4A, MAFK, IKZF5, REST, ARID2, ZBTB7A, RBM25, ATF7, ASH2L, AFF1, BCOR, TCF3, AATF, SMC3, STAG2, STAG1, NFATC3, AGO1, TRP47, CBFA2T2, ZNF207, MTA3, FOXA2, CHD2, PAF1, SS18, ZNF600, TBL1X, GTF2B, WT1, ZBTB33, CDK9, HOXB13, ZKSCAN1, ZNF580, KDM1A, YY1, RELA, CREB3L1, BCL3, ZNF148, NEUROD1, JUNB, BRG1, SP140, ZFP36, HIF1A, ZIC2, OTX2, GATA3, BATF, TAL1, MAX, ZNF143, GATA1, AGO2, HAND2, PLAG1, GFI1B, KDM5B, TP53, MYOD1, EGR2, BRD2, T, BHLHE40, AR, ARID4B, NFKBIZ, ZBTB40, EGLN2, ZBTB42, RB1, ZBTB26, RNF2, MYNN, BRD4, ILF3, JUND, HSF1, NCOR1, MAZ, ZNF24, ADNP, AHR

Target gene symbol (double-evidenced CRMs): KCNJ15,SIM2,HLCS,TTC3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000159263, ENSG00000159267, ENSG00000182670, ENSG00000157551,

eachgene

Deatailed information for cohesin site CDBP00418455