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Basic information

CohesinDB ID: CDBP00418458

Locus: chr21-36428024-36432912

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, GSE115248, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE104888, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, ENCSR193NSH, GSE206145, GSE85526, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE25021, GSE76893, ENCSR000BMY, ENCSR000EHX, ENCSR217ELF, GSE38395, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE73207, GSE72082, ENCSR501LQA, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, HSPC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, Kelly, HeLa-S3, hLCL, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, TF-1, GM12878, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, GM19099, Macrophage, MCF-7, GM12892, T-47D, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 44% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.444

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 25%, "5_TxWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: POU2F2, CEBPA, PAF1, ZFX, XBP1, DUX4, ZBTB48, WT1, PBX2, PRDM10, ERG, SP140, PRDM1, NKX2-1, CEBPB, ZEB1, ZNF121, ZMYM3, ZNF3, CTCF, SPI1, REST, HNRNPLL, BCOR, TCF3, MAZ, HCFC1R1, STAG1

Target gene symbol (double-evidenced CRMs): HLCS,KCNJ15

Function elements

Human SNPs: Pulmonary_function

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 12

Related genes and loops

Related gene: ENSG00000159267, ENSG00000157551,

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Deatailed information for cohesin site CDBP00418458