- Basic information
- CohesinDB ID: CDBP00418470
- Locus: chr21-36460801-36462870
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Data sourse: ENCSR230ZWH, GSE67783, GSE86191, GSE116868, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, ENCSR917QNE
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Cell type: RPE, Fibroblast, HCT-116, MB157, RT-112, K-562, Liver, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
89% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 31%,
"14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, PGR, XBP1, HNF1A, FOXA1, SUZ12, ATF3, NFIC, RUNX3, CBFB, ZNF189, SMARCE1, TP63, ELF1, ZNF121, TEAD1, ETV1, KLF6, SNAI2, RBM39, ESR1, HNF1B, USF2, CTCF, TCF12, KLF1, DPF2, E2F6, IRF4, ZNF528, TEAD4, ZNF92, PDX1, TFAP2C, EED, GLIS1, POU2F2, NANOG, ZSCAN5D, MYCN, ZNF263, RUNX1T1, POU5F1, ZBTB17, DUX4, ZBTB48, ZSCAN5A, STAT1, SRF, DDX5, ERG2, ERG, HOXC5, ASCL1, OGG1, ZNF341, ETS1, MYC, EZH1, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, PRDM14, IKZF1, DNMT3B, NR3C1, CEBPB, ZNF750, ESRRA, EZH2, EBF3, GABPB1, ZHX2, SPI1, EHF, IRF1, GATA2, GATAD2B, FLI1, HCFC1, MXI1, SMARCA5, MRTFB, NCOA2, RUNX1, BCL6, SMC1A, CEBPA, SIRT6, SIN3A, ZFX, SMAD3, TET2, CBX8, ERG3, ZNF18, MEF2A, CREBBP, ZNF384, RARA, TAF15, RUNX2, OSR2, NRF1, ARNT, DAXX, NCAPH2, TEAD3, ZEB1, USF1, BCL11A, SP1, NIPBL, HNF4A, REST, ASH2L, HNRNPLL, PHIP, AATF, SMC3, STAG1, ZNF394, TRP47, CBFA2T2, PPARG, FOXA2, AGO1, EBF1, ZNF692, WT1, ZNF574, ZBTB33, YY1, RELA, JUNB, BRG1, SP140, ZIC2, HIF1A, ZFP36, GATA3, MAX, NRIP1, AGO2, PLAG1, CBX2, KLF4, NCOA3, ZNF512, NR2F1, KDM5B, TP53, PKNOX1, ZNF334, ELF3, BHLHE40, AR, RXR, EGLN2, ZBTB42, HEXIM1, RB1, TFIIIC, HSF1, ZBTB26, NCOR1, BRD4, JUND, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: Kidney_stones
- Number of somatic mutations (coding): 805
- Number of somatic mutations (non-coding): 161
- Related genes and loops