Deatailed information for cohesin site CDBP00418479

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  • Basic information
  • CohesinDB ID: CDBP00418479
  • Locus: chr21-36481528-36482476
  • Data sourse: ENCSR167MTG, ENCSR338DUC, ENCSR230ZWH, GSE72082, GSE98367, GSE76893, ENCSR000BLS, ENCSR054FKH, GSE120943, ENCSR000EDW, ENCSR917QNE
  • Cell type: Macrophage, Liver, Monocytes, Hep-G2
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 4% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.956
  • Subunit: NIPBL,SA1,Rad21,SMC1,SMC3
  • CTCF binding site: non-CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 89% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 64%, "14_ReprPCWk": 16%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, CBX5, TRIM25, HMG20A, LCORL, SOX2, MEIS2, NME2, XBP1, HNF1A, FOXA1, HLF, RBFOX2, PBX2, SMAD1-5, RXRB, KDM3A, TFAP4, SIN3B, TSC22D4, ZNF90, ATF3, NFIC, THRB, ZFP64, BMI1, RUNX3, CHD7, MXD4, TP63, MITF, TEAD1, ELF1, ZNF573, RBM39, KLF6, KLF10, RCOR2, ESR1, JUN, TCF12, CTCF, BAF155, EP300, L3MBTL4, MNT, GATA6, SOX5, DPF2, SOX4, DMAP1, SIX5, IRF4, PRKDC, SMC1, RFX3, TEAD4, ZNF92, FOXA3, ZNF175, GTF2F1, GATAD2A, RBPJ, EED, MLX, TFAP2C, EHMT2, GLIS1, POU2F2, CHD8, ZSCAN5D, ZNF263, MYCN, HHEX, POU5F1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, SRF, GATAD1, SAP130, ARID3A, TBP, HNF4G, ERG, HOXC5, NFKB2, ETS1, ONECUT1, MYC, SMARCA4, MCM5, HOMEZ, RAD21, ARID1B, SMARCC2, GRHL3, RXRA, FOXK2, BATF3, GABPA, MCRS1, STAT3, ZNF614, XRCC5, NKX3-1, RCOR1, MIER3, NR2F6, HNRNPH1, VDR, NR3C1, CEBPB, HNRNPL, CREB1, CCAR2, TBL1XR1, GRHL2, ZNF652, EBF3, GABPB1, ZHX2, SPI1, MIXL1, TFE3, HBP1, IRF1, HDAC2, GATA2, SSRP1, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, MXI1, MRTFB, NFIL3, ETV5, PTBP1, RUNX1, THAP11, SMC1A, BCL6, CEBPA, SIRT6, SIN3A, ZFX, SOX13, SMAD3, TET2, CBX8, TBX3, SP5, ERG3, SMARCC1, MYBL2, CREBBP, RARA, ZBTB2, NFYC, ZNF384, RUNX2, SMAD2, GATA4, PBX4, DAXX, NRF1, ARNT, ATF2, HMGB2, SMAD4, ZNF48, PRDM9, FOXM1, PBX3, ZNF10, FOS, HMGXB4, SMARCB1, MED1, TEAD3, ZEB1, CEBPD, ZMYM3, PIAS1, U2AF1, SMAD1, ZNF3, MBD1, MAFK, SP1, NIPBL, BCL11A, HNF4A, USF1, SMAD2-3, IKZF5, REST, ARID2, ARID1A, RBM25, ZHX1, ATF7, ASH2L, HNRNPLL, PHIP, TCF3, FOXP1, SMC3, STAG1, STAG2, ETV4, NFATC3, SKI, ZNF283, CBFA2T2, PPARG, FOXA2, TBL1X, EBF1, CHD2, NFATC1, CREM, MIER2, WT1, ZNF662, ZBTB33, TCF7, ZNF580, BCL3, ZKSCAN1, KDM1A, YY1, RELA, FOXO3, HOXB13, JUNB, KAT2B, BRG1, MCM3, SP140, ZFP36, HIF1A, GATA3, BATF, TAL1, MAX, NRIP1, GATA1, ZNF143, CBX2, TLE3, CEBPG, PLAG1, NCOA3, NR2F2, KDM5B, TP53, ZBTB6, ZNF334, NFKB1, MYOD1, BRD2, PHF5A, KAT8, ELF3, ARID4B, AR, PAX3-FOXO1, TAF1, NFKBIZ, ZBTB40, BHLHE40, ZNF366, EGR1, HSF1, RNF2, ZBTB26, BRD4, JUND, CUX1, MAZ, SMAD4.1D12, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): SIM2,HLCS
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 22
  • Number of somatic mutations (non-coding): 11
  • Related genes and loops
  • Related gene: ENSG00000159263, ENSG00000159267,
  • Related loop: chr21:36421453-36423350~~chr21:36477710-36479878, chr21:36429275-36431150~~chr21:36477549-36479573, chr21:36475000-36500000~~chr21:36575000-36600000, chr21:36475000-36500000~~chr21:36725000-36750000, chr21:36475000-36500000~~chr21:36900000-36925000, chr21:36475000-36500000~~chr21:36925000-36950000, chr21:36477778-36479875~~chr21:36490518-36492345, chr21:36478462-36479768~~chr21:36588710-36590304,
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