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Basic information

CohesinDB ID: CDBP00418491

Locus: chr21-36508508-36509460

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT

Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, Hep-G2, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: Mau2,SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 40%, "15_Quies": 39%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIB, MBD3, NFIA, FOXO1, PGR, HMG20A, ZNF660, NME2, XBP1, TBL1X, FOXA1, RXRB, KDM3A, TFAP4, HDGF, TSC22D4, LYL1, ATF3, NFIC, CTCFL, RUNX3, PRDM1, WDHD1, ZNF444, MORC2, MXD4, ZNF189, SMARCE1, MECOM, TP63, DPF1, PAX5, MITF, HDAC3, MYOG, JMJD1C, KLF5, TEAD1, BCLAF1, ZNF121, ETV1, ELF1, NFE2L2, KLF6, RCOR2, ESR1, ZNF217, HNF1B, LMO2, OCA2, USF2, CTCF, JUN, SND1, BAF155, EP300, TCF12, LMO1, SOX9, SOX5, GATA6, DPF2, SOX4, IRF4, TRIM24, RAD51, ZNF776, E2F1, ZNF528, SMC1, ZNF280A, TEAD4, FOXA3, GATAD2A, EHMT2, RBPJ, EED, TFAP2C, GTF2F1, YBX1, POU2F2, CHD8, NANOG, ZSCAN5D, POU5F1, MYCN, RUNX1T1, TOP2A, HHEX, CTBP1, MTA2, ZBTB17, ZBTB48, ZSCAN5A, ERF, CDK7, UTX, SRF, DDX5, NBN, ARID3A, SAP130, HNF4G, HOXC5, ERG, PBX1, ASCL1, ZNF341, ETS1, MYC, ZNF2, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, ZNF614, NKX3-1, PRDM14, IKZF1, RCOR1, NR2F6, ARNTL, VDR, NR3C1, ESRRA, ZNF750, CEBPB, KMT2A, CREB1, TBL1XR1, EZH2, GRHL2, ZNF652, TRPS1, GABPB1, SPI1, MIXL1, IRF1, HDAC2, GATA2, ZNF644, GATAD2B, MXD3, SIX2, FLI1, DRAP1, ZGPAT, HCFC1, SMARCA5, ZNF766, RELB, NFIL3, MRTFB, NCOA2, NFYB, ETV5, RUNX1, THAP11, SMC1A, BCL6, CEBPA, NKX2-2, CBX1, SOX13, ZFX, SIN3A, POU4F2, SMAD3, ZNF654, ERG3, TET2, CBX8, ZNF770, TRIM22, SMARCC1, TWIST1, MEF2A, ZBTB2, ZNF384, RARA, ZXDC, CREBBP, NOTCH1, RUNX2, GATA4, OSR2, GR, ARNT, PBX4, DAXX, SOX11, TFDP1, HMGB2, SNIP1, SMAD4, ZEB2, ELK1, FOXM1, PBX3, PRDM9, HMGXB4, CDK8, MED1, TEAD3, PML, TERF1, MYB, SCRT2, PIAS1, SMAD1, ZMYM3, ZEB1, NR1H2, EVI1, STAT5A, KLF16, MAFK, BCL11A, NIPBL, USF1, HNF4A, TFAP2A, SP1, TRIM28, NR4A1, REST, ARID1A, ZBTB7A, ZNF479, ATF7, ASH2L, ZNF263, CTBP2, PHIP, TCF3, FOXP1, BCOR, SMC3, STAG2, STAG1, MLLT1, NFATC3, CBFA2T2, MEF2B, PPARG, ZNF207, FOXA2, EBF1, CBX3, PAF1, E2F8, MIER2, ZNF692, GTF2B, WT1, MEIS1, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, BRG1, SP140, TCF4, SKIL, HIF1A, GATA3, ZNF519, BATF, TAL1, MAX, NRIP1, ZNF143, SPIB, GATA1, PLAG1, TLE3, CEBPG, ZNF592, KLF4, BCL11B, NR2F2, ZFP69B, NR2F1, TCF7L2, KDM5B, TP53, ZNF687, PKNOX1, MED, ZNF334, MYOD1, ZNF140, ELF3, KAT8, TBX21, BHLHE40, AR, ARID4B, TAF1, ZNF579, ZBTB40, YAP1, ZBTB16, EGLN2, RB1, ZBTB26, IKZF2, BRD4, ILF3, JUND, SCRT1, CLOCK, MAZ, CUX1, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): CBR3,SIM2,CHAF1B,HLCS,KCNJ15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159231, ENSG00000159259, ENSG00000159263, ENSG00000159267, ENSG00000157551,

eachgene

Deatailed information for cohesin site CDBP00418491