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Basic information

CohesinDB ID: CDBP00418501

Locus: chr21-36523577-36525374

Data sourse: GSE206145-NatGen2015, GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 44%, "15_Quies": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, NME2, XBP1, FOXA1, SUZ12, ATF3, MITF, ESR1, OCA2, USF2, CTCF, EP300, KLF1, PAX8, E2F6, TEAD4, POU2F2, CHD8, ZSCAN5D, MYCN, ZNF263, TOP2A, ZBTB48, ZSCAN5A, DUX4, DDX5, ERG, MYC, SMARCA4, EOMES, GRHL3, NKX2-1, GABPA, STAT3, NKX3-1, IKZF1, DNMT3B, EZH2, BMPR1A, GRHL2, SIX2, PTBP1, RUNX1, SMC1A, NKX2-2, ZFX, TET2, ERG3, CBX8, PRDM10, CREBBP, ARNT, PRDM9, ETV6, CBFA2T3, SMARCB1, CHD1, FOS, MED1, ZEB1, SCRT2, USF1, POU2F3, SMC3, STAG1, NFATC3, TBL1X, EBF1, WT1, ZNF662, ZKSCAN1, YY1, RELA, ZNF19, SP140, TAL1, MAX, ZNF143, GATA1, PLAG1, CBX2, NR2F1, ZBTB6, PKNOX1, ZNF334, PAX3-FOXO1, ZNF445, AR, ZBTB40, HSF1, RNF2, SCRT1, CLOCK, MAZ

Target gene symbol (double-evidenced CRMs): KCNJ15,CHAF1B,SIM2,HLCS,CBR3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 12

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000159231, ENSG00000159259, ENSG00000159263, ENSG00000159267, ENSG00000157551,

eachgene

Deatailed information for cohesin site CDBP00418501