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Basic information

CohesinDB ID: CDBP00418524

Locus: chr21-36584895-36585487

Data sourse: ENCSR000BLD, ShirahigeLab-GSE177045, GSE72082, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE138405, GSE76893, GSE101921, GSE135093, GSE152721, ShirahigeLab-NatGen2015, GSE112028, ENCSR703TNG, GSE116344, GSE145327, GSE94872, ENCSR000EEG, ENCSR000BLS, ShirahigeLab, GSE85526, ENCSR000ECE, ENCSR000BMY, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS

Cell type: MDM, RH4, GM10847, GM2610, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, H1-hESC, SNYDER, GM18505, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HAP1, GM19099, HUES64, MCF-7, GM12892, THP-1, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM19238, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 28% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.511

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 41%, "14_ReprPCWk": 40%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, SKI, PGR, SMC1A, SMARCA2, FOXA2, ZFX, DUX4, FOXA1, CDK9, TRIM22, HOXB13, SMARCC1, ERG, YY1, ZBTB2, NEUROD1, ZNF112, ONECUT1, MYC, GR, RUNX3, RAD21, GRHL3, ARNT, GATA3, PRDM9, GABPA, ETV6, NKX3-1, HDAC3, NR3C1, TEAD1, TRIM28, MYB, PIAS1, EZH2, KDM5B, ESR1, GRHL2, ZNF334, CTCF, ELF3, SPI1, BAF155, AR, HDAC2, GATA2, REST, IRF4, EGLN2, ZNF366, FLI1, ASH2L, RNF2, BRD4, ILF3, BCOR, FOXP1, SMC1, SMC3, ZNF24, STAG1

Target gene symbol (double-evidenced CRMs): SIM2,KCNJ6,DOP1B,HLCS,CHAF1B,CBR3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000159231, ENSG00000142197, ENSG00000159259, ENSG00000159263, ENSG00000159267, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418524