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Basic information

CohesinDB ID: CDBP00418526

Locus: chr21-36587320-36592079

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, ShirahigeLab, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, ShirahigeLab-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, ShirahigeLab-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, HeLa, TC-71, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 72% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.222

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 43%, "15_Quies": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, FOXA1, SUZ12, ATF3, ZFP64, PRDM1, SMARCE1, ELF1, TEAD1, ZNF217, ESR1, JUN, CTCF, MNT, ZBTB20, DPF2, ZNF528, SMC1, TFAP2C, MYCN, CTBP1, ZBTB17, ZBTB48, ZSCAN5A, HOXC5, USP7, MYC, RFX1, RAD21, GRHL3, NKX2-1, STAT3, PRDM14, RCOR1, NR3C1, ZNF750, CREB1, EZH2, GRHL2, HDAC2, SMC1A, CBX1, SIN3A, ZFX, SMAD3, CBX8, CREBBP, ZNF384, RUNX2, GATA4, GR, PBX4, ARNT, FOS, CDK8, NCOA1, ZNF22, SP1, PHIP, STAG1, FOXA2, WT1, YY1, RELA, JUNB, NEUROD1, BRG1, HIF1A, GATA3, MAX, NRIP1, ZNF143, MTA1, GATA1, NR2F1, KDM5B, TP53, BRD2, AR, ZNF579, EGLN2, HSF1, BRD4, JUND, CLOCK, CUX1, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): CBR3,HLCS,SIM2,DOP1B,KCNJ6,CHAF1B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 15

Related genes and loops

Related gene: ENSG00000159231, ENSG00000142197, ENSG00000159259, ENSG00000159263, ENSG00000159267, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418526