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Basic information

CohesinDB ID: CDBP00418531

Locus: chr21-36604225-36607299

Data sourse: ENCSR000BLD, GSE67783, ENCSR000BKV, GSE86191, GSE110061, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, GSE206145, ENCSR153HNT

Cell type: RPE, H1-hESC, Fibroblast, HCT-116, K-562, HSPC, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 42%, "15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, FOXA1, ZFHX2, ZNF90, ATF3, ATF4, MITF, ZNF629, ESR1, OCA2, JUN, CTCF, TFAP2C, ZNF425, ZSCAN5D, MYCN, ZNF263, POU5F1, ZBTB48, ZSCAN5A, STAT1, SRF, ERG2, ZBTB21, MYC, SMARCA4, RAD21, STAT3, XRCC5, HNRNPH1, NR3C1, CEBPB, CREB1, EZH2, ZNF565, GABPB1, ZHX2, KLF17, GATA2, SIX2, FLI1, ZNF554, ETV5, RUNX1, SMC1A, SIRT6, FIP1L1, ZFX, TET2, ERG3, SMARCC1, ZNF133, GR, ATF2, CHD1, TEAD3, BCL11A, ZNF479, ATF7, HNRNPLL, PRDM6, AATF, SMC3, STAG1, TRP47, CBFA2T2, FOXA2, WT1, YY1, RELA, BRG1, SP140, ZIC2, HIF1A, GATA3, ZNF519, ZNF143, MYOD1, EGR2, AR, PAX3-FOXO1, HEXIM1, HSF1, MYNN, NOTCH3, BRD4, JUND, MAZ

Target gene symbol (double-evidenced CRMs): HLCS,CHAF1B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 15

Related genes and loops

Related gene: ENSG00000159259, ENSG00000159267,

eachgene

Deatailed information for cohesin site CDBP00418531