- Basic information
- CohesinDB ID: CDBP00418532
- Locus: chr21-36612683-36613591
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Data sourse: ENCSR167MTG, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT, ENCSR703TNG, GSE25021
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Cell type: MCF-7, Fibroblast, HCT-116, Hep-G2, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"14_ReprPCWk": 48%,
"15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, PGR, HMG20A, NME2, XBP1, FOXA1, RXRB, ATF3, IKZF3, ATF4, MXD4, SMARCE1, MITF, TEAD1, ELF1, ZNF121, LMO2, ESR1, OCA2, CTCF, JUN, SND1, BAF155, EP300, MNT, SOX5, DPF2, PRKDC, E2F1, SMC1, TEAD4, FOXA3, GATAD2A, TFAP2C, RBPJ, MLX, JARID2, POU2F2, CHD8, ZSCAN5D, ZNF263, SRC, RUNX1T1, CDK7, KDM4C, CTBP1, POU5F1, DUX4, ZBTB48, ZSCAN5A, SRF, GATAD1, SAP130, ERG2, SP4, HOXC5, ERG, ETS1, MYC, HOMEZ, RAD21, GRHL3, NKX2-1, GABPA, ZNF614, XRCC5, NKX3-1, PRDM14, MIER3, NR2F6, NR3C1, ESRRA, CEBPB, CREB1, EZH2, GRHL2, ZNF652, TRPS1, MIXL1, TFE3, HDAC2, GATA2, ZNF644, MXD3, DRAP1, MXI1, NFIL3, NCOA2, ETV5, RUNX1, SMC1A, BCL6, CEBPA, SOX13, ZFX, SIN3A, SMAD3, ERG3, SP5, TRIM22, PRDM10, CREBBP, RARA, ZXDC, ZBTB2, ZNF35, CDK6, GATA4, GR, PBX4, DAXX, SOX11, ARNT, ZNF48, SMAD4, CDK8, HMGXB4, MED1, TEAD3, ZNF680, PIAS1, NCOA1, NIPBL, TFAP2A, IKZF5, ZBTB7A, ASH2L, MBD2, FOXP1, SMC3, STAG1, CBFA2T2, PPARG, FOXA2, WT1, ESR2, TCF7, HOXB13, ZNF580, KDM1A, YY1, RELA, BRG1, MCM3, SP140, HIF1A, GATA3, MAX, NRIP1, ZNF143, CEBPG, NCOA3, NR2F2, TCF7L2, KDM5B, ZNF687, TP53, ZNF334, EGR2, ELF3, KAT8, ARRB1, ARID4B, AR, BHLHE40, EGLN2, ZBTB26, RNF2, NOTCH3, BRD4, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): CHAF1B,HLCS
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 4
- Related genes and loops