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Basic information

CohesinDB ID: CDBP00418544

Locus: chr21-36647229-36648099

Data sourse: ENCSR000EEG, ENCSR338DUC, GSE67783, GSE72082, ENCSR000BLS, GSE105028, GSE101921, ENCSR054FKH, GSE206145, ENCSR000EDE, GSE68388, ENCSR703TNG, GSE25021, ENCSR330ELC, GSE94872, ENCSR000ECS, GSE64758

Cell type: MCF-7, H1-hESC, RPE, Hep-G2, A-549, HUVEC, HCAEC, HeLa-S3, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 35%, "15_Quies": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, PGR, HMG20A, SOX2, XBP1, FOXA1, RXRB, KDM3A, TFAP4, ATF3, THRB, CHD7, MXD4, SMARCE1, MITF, CDX2, TEAD1, ZNF573, KLF6, RCOR2, ESR1, HNF1B, USF2, JUN, CTCF, EP300, SOX9, GATA6, SOX5, DPF2, SOX4, E2F6, DMAP1, E2F1, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, MLX, RBPJ, TFAP2C, NANOG, CHD8, CTBP1, ZBTB48, ZSCAN5A, GATAD1, SAP130, ERG2, ERG, HOXC5, ASCL1, ETS1, MYC, EZH1, SMARCA4, KDM4A, HOMEZ, RAD21, GRHL3, PROX1, NKX2-1, GABPA, STAT3, XRCC5, ZNF614, PRDM14, IKZF1, MIER3, HNRNPH1, NR2F6, NR3C1, ESRRA, CEBPB, CREB1, CCAR2, TBL1XR1, BMPR1A, GRHL2, ZNF652, GABPB1, ZHX2, SPI1, MIXL1, TFE3, IRF1, HDAC2, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, ZGPAT, NFIL3, NCOA2, ZNF554, MRTFB, ETV5, RUNX1, THAP11, BCL6, CBX1, CEBPA, SOX13, ZFX, POU4F2, SMAD3, SP5, ZNF18, SMARCC1, RARA, CREBBP, ZNF384, NFYC, RUNX2, SMAD2, GATA4, ARNT, DAXX, PBX4, ZNF48, HMGB2, SMAD4, FOS, CDK8, HMGXB4, TGIF2, MED1, TEAD3, ZEB1, SUPT16H, ZNF3, C11orf30, RBM22, MAFK, NIPBL, USF1, HNF4A, IKZF5, ASH2L, HNRNPLL, FOXP1, SMC3, NCOR2, STAG2, STAG1, ZNF316, FOXA2, PPARG, CBX3, MIER2, ZSCAN16, WT1, MAFF, ZNF580, ZKSCAN1, KDM1A, YY1, RELA, JUNB, BRG1, MCM3, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, KLF4, CEBPG, NR2F2, TP53, MYOD1, ELF3, T, BRD2, KAT8, PHF5A, BHLHE40, AR, ARID4B, EGLN2, ZBTB26, RNF2, HSF1, BRD4, JUND, NCOR1, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): HLCS,CHAF1B,CBR3,SIM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000159231, ENSG00000159259, ENSG00000159263, ENSG00000159267,

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Deatailed information for cohesin site CDBP00418544