Deatailed information for cohesin site CDBP00418568

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  • Basic information
  • CohesinDB ID: CDBP00418568
  • Locus: chr21-36717947-36720220
  • Data sourse: ENCSR167MTG, ENCSR000EEG, GSE67783, GSE72082, GSE86191, ENCSR000BSB, GSE126634, GSE116868, GSE138405, GSE111913, GSE25021, ENCSR000BLS, GSE105028, GSE51234, ENCSR054FKH, GSE206145-NatGen2015, GSE206145, ENCSR153HNT, GSE131606, GSE38411
  • Cell type: RPE, Fibroblast, HCT-116, Hela-Kyoto, Hep-G2, MB157, DKO, RT-112, HSPC, K-562, BCBL-1, GP5d, HAP1, H9-hESC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 7% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.844
  • Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 92% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "14_ReprPCWk": 41%, "13_ReprPC": 18%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, KDM3A, HDGF, THAP1, ZBTB44, IKZF3, MORC2, SFPQ, TEAD1, ZNF121, LMO2, OCA2, ZNF561, SOX5, PAX8, DEK, E2F4, ZNF674, ZNF528, GATAD2A, JARID2, NANOG, ZNF263, BRD3, POU5F1, TOP2A, CTBP1, DUX4, STAT1, ZNF134, SAP130, ERG, PAX6, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, HCFC1R1, RUNX1, HDAC1, NKX2-2, CEBPA, REPIN1, TET2, SP5, SMARCC1, PRDM10, ZBTB2, CBX4, ELK1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PIAS1, NR1H2, C11orf30, ARID2, IKZF5, RBM25, MBD2, ELL2, NFATC3, CBFA2T2, CBX3, CHD2, SS18, PAF1, ZSCAN16, WT1, NEUROD1, JUNB, MCM3, ZFP36, TCF4, BATF, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, BCL6B, EGR2, RBM14, ZNF765, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ZNF316, FOSL1, SMARCA2, ZNF660, XBP1, PBX2, ZNF596, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, ZNF273, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, MYOG, MAF, ELF1, RBM39, SNAI2, KLF10, ZNF624, CTCF, JUN, TAF3, L3MBTL4, ZBTB20, MNT, LMO1, RYBP, DPF2, ZNF423, ZNF677, PDX1, TFAP2C, RBPJ, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, DDX5, CHD4, ONECUT1, ZNF2, KDM4A, TSHZ1, RXRA, BATF3, NKX3-1, PRDM14, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, KLF8, GRHL2, ZNF565, ZBTB14, SSRP1, ZSCAN29, SMARCA5, THAP11, CTNNB1, ZBTB24, EZH2phosphoT487, SOX13, AFF4, ZNF770, ZNF513, ZNF18, SP3, ARNT, BACH1, DAXX, NFIB, ZNF48, PRDM9, ZEB2, NCAPH2, ZNF10, HMGXB4, TEAD3, ZXDB, ZNF680, TAF7, KLF9, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, PCGF2, CTBP2, GLIS2, PRDM6, ZNF623, SMC3, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, ZNF141, ZNF768, TP53, ZNF645, ZNF334, ZNF140, BRD2, KAT8, ARRB1, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, ZSCAN23, ZNF468, PGR, SOX2, PATZ1, RING1B, UBTF, TFAP4, BMI1, CHD7, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, ZNF524, KLF1, SOX9, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, ZSCAN5D, KDM4C, ZSCAN5A, ELK4, ERG2, HIC1, SP4, TBP, HOXC5, OGG1, ETS1, MYC, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, SRSF3, EZH2, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, GATAD2B, ZNF777, ZNF76, ETV5, BCL6, SIN3A, ZFP37, ERG3, CREBBP, ZNF35, RARA, ZNF384, TAF15, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, SREBF2, ZNF22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, HDAC6, ZNF44, ZNF692, GTF2B, YY2, RELA, TARDBP, ZNF611, MGA, MAX, ZNF592, NR2F1, TCF7L2, KDM5B, ZNF791, MYOD1, AR, ZNF445, YAP1, ZNF324, RBAK, HEXIM1, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, ZSCAN5C, HMGN3, SUZ12, RBFOX2, ZNF28, ZFHX2, SFMBT1, ZNF90, INSM2, NFIC, CTCFL, ZBTB5, PRDM1, KLF14, HDAC3, ZNF736, CDX2, ZNF629, ZNF506, KLF5, TRIM28, BCLAF1, ETV1, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, CDK7, GATAD1, ZNF585B, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, EHF, IRF1, ZGPAT, MRTFB, MYF5, PTBP1, SMC1A, CBX1, MAFG, SIRT6, FIP1L1, ZFX, ZNF534, NFKBIA, ZNF335, SMAD3, CBX8, TWIST1, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, NRF1, PBX4, CHD1, FOS, MED1, KDM6B, MYB, SCRT2, L3MBTL2, SETDB1, KLF16, NUP98-HOXA9, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, ZNF783, PAX7, NELFA, ZNF283, FOXA2, RBBP5, ZNF600, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF449, GATA1, CEBPG, SP7, NR2F2, ZNF512, BHLHE40, NFKBIZ, TAF1, ZNF846, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): CHAF1B,HLCS,SIM2
  • Function elements
  • Human SNPs: Height
  • Number of somatic mutations (coding): 35
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000159259, ENSG00000159263, ENSG00000159267,
  • Related loop: chr21:33025000-33050000~~chr21:36700000-36725000, chr21:36400000-36425000~~chr21:36700000-36725000, chr21:36475000-36500000~~chr21:36725000-36750000, chr21:36500000-36525000~~chr21:36725000-36750000, chr21:36575000-36600000~~chr21:36725000-36750000, chr21:36625000-36650000~~chr21:36725000-36750000, chr21:36700000-36725000~~chr21:36850000-36875000, chr21:36700000-36725000~~chr21:36900000-36925000, chr21:36700000-36725000~~chr21:36925000-36950000, chr21:36725000-36750000~~chr21:36900000-36925000, chr21:36725000-36750000~~chr21:36925000-36950000, chr21:36725000-36750000~~chr21:37050000-37075000,
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