- Basic information
- CohesinDB ID: CDBP00418581
- Locus: chr21-36744439-36745359
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Data sourse: ENCSR000BTU, GSE67783, GSE86191, GSE131956, GSE116868, ENCSR000BLY, GSE206145, GSE101921, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EHX, GSE106870, GSE38411
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Cell type: RPE, Fibroblast, HCT-116, MB157, Ishikawa, HCAEC, CVI-hiPSC, GBM39, K-562, SK-N-SH, BCBL-1, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 34%,
"13_ReprPC": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, FOXO1, NFIA, TRIM25, PGR, HMG20A, HMGN3, MEIS2, SOX2, XBP1, FOXA1, SUZ12, RBFOX2, RING1B, UBTF, KDM3A, TFAP4, ZNF90, THRB, ATF3, NFIC, BMI1, THAP1, CTCFL, CHD7, PRDM1, ZFP64, CBFB, MXD4, ZNF189, SMARCE1, PAX5, TP63, ZNF736, ZNF467, TEAD1, TRIM28, ELF1, ETV1, SNAI2, KLF6, RBM39, LMO2, ESR1, OCA2, MLL, PITX3, USF2, CTCF, TCF12, JUN, EP300, GATA6, SOX5, DPF2, RYBP, E2F6, DMAP1, TRIM24, E2F4, E2F1, SMC1, TEAD4, FOXA3, KMT2B, GATAD2A, PDX1, TFAP2C, EED, RBPJ, JARID2, POU2F2, NANOG, BRD1, ZSCAN5D, MYCN, ZNF263, TOP2A, ID3, POU5F1, CTBP1, RUNX1T1, ZBTB17, ZBTB48, ZSCAN5A, ZNF649, STAT1, NONO, ERF, GATAD1, DDX5, SAP130, ERG2, SP4, ARID3A, TBP, ERG, OGG1, ZBTB8A, ZNF341, MYC, SMARCA4, EOMES, KDM4A, RAD21, FOXP2, GRHL3, RFX1, PROX1, NKX2-1, RXRA, GABPA, STAT3, XRCC5, APC, NKX3-1, PRDM14, IKZF1, RCOR1, DNMT3B, NR2F6, ZNF614, VDR, INO80, NR3C1, ESRRA, HNRNPL, CREB1, EZH2, CHD8, GRHL2, ZNF652, EBF3, GABPB1, PHF8, ZHX2, SPI1, HBP1, MIXL1, PCBP1, HDAC2, GATA2, GATAD2B, MXD3, SIX2, HCFC1, MXI1, ZGPAT, SMARCA5, NFIL3, MYF5, ATF1, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CBX1, EZH2phosphoT487, CEBPA, SIRT6, SIN3A, ZFX, SOX13, FIP1L1, NKX2-2, SMAD3, TET2, ERG3, CBX8, ZNF770, SMARCC1, RARA, ZNF384, NFYC, CREBBP, ZBTB2, TAF15, RUNX2, SMAD2, PRPF4, GATA4, NRF1, ARNT, BACH1, ZNF48, PRDM9, SMAD4, NFYA, ATF2, PBX3, NCAPH2, NR2C1, SMARCB1, CHD1, SNRNP70, HMGXB4, MAFB, MED1, CDK8, ZEB1, TEAD3, CEBPD, KDM6B, SCRT2, ZMYM3, KLF9, L3MBTL2, GTF3C2, ZNF22, RBM22, MAFK, BCL11A, SP1, TFAP2A, HNF4A, USF1, NIPBL, IKZF5, REST, ARID1A, ZBTB7A, RBM25, CCNT2, ARID2, ZHX1, ASH2L, HNRNPLL, TCF3, BCOR, MBD2, FOXP1, AATF, SMC3, STAG1, HMGB1, STAG2, SKI, TRP47, CBFA2T2, ZNF316, AGO1, FOXA2, RBBP5, CREM, PAF1, SS18, ZNF600, PPARG, CHD2, WT1, ESR2, ZBTB33, MEF2C, HOXB13, ZKSCAN1, ZNF580, KDM1A, YY1, RELA, FOXO3, TARDBP, BCL3, NEUROD1, BRG1, SP140, ZFP36, HIF1A, ZIC2, PCGF1, ZNF519, MAF1, MAX, TAL1, NRIP1, ZNF143, AGO2, CBX2, PLAG1, KLF4, CEBPG, GFI1B, NR2F2, NCOA3, ZNF512, NR2F1, KDM5B, TP53, ZNF334, EGR2, ELF3, BHLHE40, AR, ARID4B, TAF1, NFKBIZ, ZNF445, RXR, ZBTB40, ZNF366, HEXIM1, EGR1, TFIIIC, HSF1, RNF2, ZBTB26, SCRT1, BRD4, RB1, CLOCK, JUND, MAZ, TBX2, AHR
- Target gene symbol (double-evidenced CRMs): HLCS,SIM2,TTC3
- Function elements
- Human SNPs: Cerebellum_cortex_volume
- Number of somatic mutations (coding): 74
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159263,
ENSG00000159267,
ENSG00000182670,
- Related loop:
chr21:36475000-36500000~~chr21:36725000-36750000,
chr21:36500000-36525000~~chr21:36725000-36750000,
chr21:36575000-36600000~~chr21:36725000-36750000,
chr21:36625000-36650000~~chr21:36725000-36750000,
chr21:36725000-36750000~~chr21:36900000-36925000,
chr21:36725000-36750000~~chr21:36925000-36950000,
chr21:36725000-36750000~~chr21:37050000-37075000,
chr21:36746594-36748679~~chr21:36926513-36928814,
chr21:36746609-36749083~~chr21:36853704-36855509,
chr21:36746609-36749083~~chr21:36916830-36918749,
chr21:36746609-36749083~~chr21:36926698-36929094,
chr21:36746645-36749017~~chr21:36926642-36928684,
chr21:36746707-36748632~~chr21:36917076-36918400,
chr21:36746841-36748820~~chr21:36853768-36855574,
chr21:36746841-36748820~~chr21:36926678-36929090,
chr21:36746942-36748770~~chr21:36853698-36855512,
chr21:36746942-36748770~~chr21:36916749-36918779,
chr21:36746944-36749154~~chr21:36916612-36918723,
chr21:36746944-36749154~~chr21:36926687-36928814,
chr21:36746957-36749111~~chr21:36916838-36918727,
chr21:36746964-36748885~~chr21:36853704-36855614,
chr21:36746970-36748653~~chr21:36853694-36855322,
chr21:36747017-36748924~~chr21:36926717-36928685,
chr21:36747198-36748728~~chr21:36926753-36928677,
chr21:36747249-36749170~~chr21:36926465-36928856,
chr21:36747295-36748582~~chr21:36926942-36928578,
chr21:36750000-36775000~~chr21:36850000-36875000,
chr21:36750000-36775000~~chr21:36900000-36925000,