- Basic information
- CohesinDB ID: CDBP00418586
- Locus: chr21-36752882-36754752
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Data sourse: ENCSR000BLD, ENCSR000EFJ, GSE126990, GSE86191, GSE138405, GSE110061, ENCSR000HPG, GSE111913, GSE76893, GSE105028, GSE206145-NatGen2015, GSE135093, GSE206145, ENCSR000EDE, GSE68388, ENCSR495WGO, ENCSR000ECS, GSE165895
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Cell type: RPE, H1-hESC, Fibroblast, HCT-116, Hela-Kyoto, A-549, HeLa-S3, IMR-90, RT-112, HFFc6, HuCC-T1, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 56%,
"7_Enh": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PGR, XBP1, FOXA1, ATF3, CTCFL, PRDM1, TEAD1, ZNF121, ESR1, JUN, CTCF, TCF12, EP300, BAF155, SOX4, E2F1, TEAD4, TFAP2C, CHD8, ZNF263, MYCN, POU5F1, ZBTB48, STAT1, TBP, PAX6, ERG, OGG1, SMARCA4, RAD21, LHX2, GRHL3, STAT3, NKX3-1, GFI1, RCOR1, NR3C1, CEBPB, SRSF3, ZHX2, SPI1, GATA2, MRTFB, RUNX1, SMC1A, ZFX, SMAD3, TET2, ZNF770, SMARCC1, CREBBP, RUNX2, GATA4, PBX4, DAXX, FOS, SMARCB1, MED1, PIAS1, RBM22, SP1, REST, ASH2L, FOXP1, AATF, SMC3, TRP47, FOXA2, AGO1, TBL1X, PAF1, SS18, ZNF600, WT1, ESR2, ZBTB33, MEF2C, HOXB13, YY1, RELA, JUNB, SP140, TAL1, ZNF143, TLE3, KDM5B, MYOD1, BHLHE40, AR, RXR, HSF1, NCOR1, NOTCH3, BRD4, MAZ, FOSL2
- Target gene symbol (double-evidenced CRMs): HLCS,SIM2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 192
- Number of somatic mutations (non-coding): 64
- Related genes and loops
- Related gene:
ENSG00000159263,
ENSG00000159267,
- Related loop:
chr21:36475000-36500000~~chr21:36725000-36750000,
chr21:36500000-36525000~~chr21:36725000-36750000,
chr21:36575000-36600000~~chr21:36725000-36750000,
chr21:36625000-36650000~~chr21:36725000-36750000,
chr21:36725000-36750000~~chr21:36900000-36925000,
chr21:36725000-36750000~~chr21:36925000-36950000,
chr21:36725000-36750000~~chr21:37050000-37075000,
chr21:36746594-36748679~~chr21:36926513-36928814,
chr21:36746609-36749083~~chr21:36853704-36855509,
chr21:36746609-36749083~~chr21:36916830-36918749,
chr21:36746609-36749083~~chr21:36926698-36929094,
chr21:36746645-36749017~~chr21:36926642-36928684,
chr21:36746707-36748632~~chr21:36917076-36918400,
chr21:36746841-36748820~~chr21:36853768-36855574,
chr21:36746841-36748820~~chr21:36926678-36929090,
chr21:36746942-36748770~~chr21:36853698-36855512,
chr21:36746942-36748770~~chr21:36916749-36918779,
chr21:36746944-36749154~~chr21:36916612-36918723,
chr21:36746944-36749154~~chr21:36926687-36928814,
chr21:36746957-36749111~~chr21:36916838-36918727,
chr21:36746964-36748885~~chr21:36853704-36855614,
chr21:36746970-36748653~~chr21:36853694-36855322,
chr21:36747017-36748924~~chr21:36926717-36928685,
chr21:36747198-36748728~~chr21:36926753-36928677,
chr21:36747249-36749170~~chr21:36926465-36928856,
chr21:36747295-36748582~~chr21:36926942-36928578,
chr21:36750000-36775000~~chr21:36850000-36875000,
chr21:36750000-36775000~~chr21:36900000-36925000,