- Basic information
- CohesinDB ID: CDBP00418598
- Locus: chr21-36772578-36774299
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Data sourse: ENCSR000EFJ, ENCSR167MTG, ENCSR338DUC, ENCSR230ZWH, GSE67783, GSE72082, GSE165895, GSE86191, GSE116868, GSE129526, ENCSR000HPG, GSE111913, GSE76893, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, GSE68388, ENCSR703TNG, ENCSR917QNE
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hep-G2, MB157, IMR-90, RT-112, Liver, HSPC, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 10% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 44%,
"5_TxWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, TRIM25, PGR, HMG20A, XBP1, FOXA1, RXRB, KDM3A, TFAP4, ATF3, NFIC, THRB, ZFP64, MXD4, TP63, CDX2, TEAD1, RCOR2, ESR1, OCA2, USF2, JUN, TCF12, CTCF, BAF155, EP300, SOX5, SOX4, E2F6, TRIM24, E2F1, TEAD4, FOXA3, ZNF175, GATAD2A, RBPJ, TFAP2C, POU2F2, CHD8, ZSCAN5D, MYCN, POU5F1, ZNF263, TOP2A, ZBTB48, ZSCAN5A, GATAD1, DDX5, SAP130, ERG, HOXC5, ASCL1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, ZNF614, NKX3-1, RCOR1, MIER3, NR2F6, NR3C1, CEBPB, ZNF750, CREB1, TBL1XR1, GRHL2, GABPB1, ZHX2, SPI1, TFE3, MIXL1, HDAC2, GATA2, ZNF644, FLI1, DRAP1, ZGPAT, MYF5, ETV5, PTBP1, RUNX1, THAP11, SMC1A, BCL6, CEBPA, SOX13, ZFX, SMAD3, ZNF770, TET2, TWIST1, CREBBP, ZNF384, RARA, RUNX2, DAXX, PBX4, ARNT, NRF1, ZNF48, ZNF708, SMAD4, PBX3, FOS, CDK8, HMGXB4, MED1, CSNK2A1, TEAD3, PIAS1, KLF9, RBM22, SP1, GSPT2, HNF4A, IKZF5, REST, ASH2L, PHIP, FOXP1, SMC3, STAG1, ZNF394, SKI, TRP47, PPARG, FOXA2, TBL1X, WT1, HOXB13, ZNF580, KDM1A, YY1, RELA, NEUROD1, JUNB, SP140, HIF1A, OTX2, GATA3, MAX, NRIP1, ZNF143, CEBPG, KLF4, NCOA3, NR2F2, NEUROG2, NR2F1, KDM5B, TCF7L2, TP53, MYOD1, ELF3, KAT8, NFKBIZ, AR, ARID4B, BHLHE40, ZBTB42, HSF1, ZBTB26, JUND, BRD4, CUX1, MAZ, BRCA1, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): HLCS
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 21
- Number of somatic mutations (non-coding): 0
- Related genes and loops