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Basic information

CohesinDB ID: CDBP00418645

Locus: chr21-36902278-36903030

Data sourse: GSE67783, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE165895

Cell type: RPE, Fibroblast, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 56%, "15_Quies": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFATC3, GLIS1, POU2F2, SMC1A, CHD8, HDAC1, ZNF263, POU5F1, TOP2A, KDM4C, ZFX, CTBP1, ZNF317, XBP1, WT1, ZBTB48, POU4F2, RUNX1T1, MEIS2, SRF, TET2, MAFF, PBX2, TBP, MYCN, YY1, RELA, MIER1, EHMT2, ATF3, RUNX2, CDK6, RUNX3, SP140, ZIC2, HIF1A, ATF2, ZEB2, HMBOX1, SMARCE1, MAX, ZNF143, SNRNP70, MIER2, CBX2, ARNTL, NR3C1, MAF, GFI1B, TP53, NCOA1, MAFG, C11orf30, JUN, CTCF, RBM22, SPI1, KLF1, MAFK, MNT, AR, KLF17, FOXA2, BCL11A, REST, ATF7, ZBTB26, RNF2, MXI1, BRD4, JUND, MAZ, SMC3, STAG1, ZNF316

Target gene symbol (double-evidenced CRMs): HLCS,CBR3,CHAF1B,SIM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 18

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159231, ENSG00000159259, ENSG00000159263, ENSG00000159267,

eachgene

Deatailed information for cohesin site CDBP00418645