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Basic information

CohesinDB ID: CDBP00418647

Locus: chr21-36908112-36912037

Data sourse: ENCSR000BLD, GSE104888, GSE72082, ENCSR501LQA, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR000DYE, ENCSR000EFJ, GSE165895, GSE25021, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR806UKK, GSE138105, ENCSR199XBQ, GSE116344, ENCSR895JMI, ENCSR000EEG, ENCSR193NSH, ENCSR768DOX, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, GSE68388, GSE83726, GSE126990, ENCSR000ECS, ENCSR481YWD

Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Hela-Kyoto, Hep-G2, RH4, SLK, A-549, HeLa-S3, IMR-90, HSPC, SK-N-SH, RT-112, HFFc6, HuCC-T1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 27% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.800

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 41%, "15_Quies": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, FOXO1, FOSL1, ZNF391, PGR, TRIM25, ZNF660, ZSCAN5C, XBP1, PATZ1, FOXA1, ZFHX2, TFAP4, ATF3, BMI1, INSM2, ZFP64, ZNF362, CHD7, PRDM1, IKZF3, KLF14, ATF4, ZNF189, SMARCE1, TP63, ZNF320, CDX2, ZNF629, JMJD1C, MAF, TEAD1, ZNF121, TRIM28, KLF6, SNAI2, ELF1, KLF10, ZNF217, ESR1, HNF1B, NFE2L2, ZNF573, OCA2, MLL, USF2, CTCF, TCF12, JUN, EP300, NUTM1, BAF155, KLF1, ZNF157, GATA6, DPF2, SOX4, PAX8, SIX5, TRIM24, RFX5, E2F1, ZNF528, TEAD4, GATAD2A, PDX1, GTF2F1, EED, TFAP2C, GLIS1, POU2F2, POU5F1, BRD3, MYCN, ZNF263, CTBP1, ZSCAN21, ZBTB17, DUX4, ZBTB48, STAT1, ZBTB1, SRF, DDX5, ARID3A, HIC1, SP4, TBP, HOXC5, ZBTB21, ERG, CHD4, ASCL1, OGG1, ZBTB8A, ETS1, ONECUT1, MYC, SMARCA4, RFX1, TSHZ1, RAD21, ZNF2, GRHL3, RXRA, NKX2-1, BATF3, GABPA, STAT3, NKX3-1, PRDM14, MIER3, RCOR1, ZNF639, ARNTL, NR3C1, CEBPB, ESRRA, ZNF750, CREB1, EZH2, KLF8, BMPR1A, FEZF1, MRTFA, ZHX2, SPI1, ZNF664, EHF, IRF1, KLF17, GATA2, ETV1, ZNF146, SREBF1, FLI1, MRTFB, NFIL3, ZNF554, MYF5, CTNNB1, SMC1A, BCL6, CEBPA, NKX2-2, RBM39, AFF4, ZFX, SIN3A, ZNF335, SMAD3, ZNF770, SMARCC1, PRDM10, RARA, ZNF384, ZNF35, CREBBP, RUNX2, GATA4, OSR2, ZNF184, SP3, PBX4, ARNT, NRF1, ZBTB10, DAXX, ATF2, ZEB2, ZNF518A, PBX3, MAFB, FOXM1, FOS, CDK8, CHD1, SMARCB1, MED1, TEAD3, ZEB1, ZXDB, ZNF558, SCRT2, CEBPD, PIAS1, NR1H2, SETDB1, MAFK, NIPBL, SP1, BCL11A, HNF4A, USF1, REST, ARID1A, OVOL3, ATF7, ZHX1, PHIP, GLIS2, FOXP1, PRDM6, AATF, ZNF623, SMC3, ELL2, STAG1, ZNF394, NELFA, CBFA2T2, PPARG, FOXA2, TBL1X, CHD2, ZNF600, ZNF692, WT1, MAFF, ZNF574, ZBTB33, MEF2C, HOXB13, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, NEUROD1, BRCA1, SP140, TCF4, ZFP36, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, ZNF143, AGO2, TLE3, ZFP69B, ZNF592, CEBPG, KLF4, SP7, NCOA3, TCF7L2, NEUROG2, KDM5B, ZNF687, PKNOX1, TP53, NFKB1, BCL6B, MYOD1, EGR2, BRD2, ELF3, ZNF843, BHLHE40, AR, TAF1, RXR, ZNF324, YAP1, EGLN2, ZNF366, ZBTB42, HSF1, RNF2, NCOR1, BRD4, JUND, SCRT1, CLOCK, CUX1, MAZ, ZSCAN23, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): CBR3,HLCS,CHAF1B,SIM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 42

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159231, ENSG00000159259, ENSG00000159263, ENSG00000159267,

eachgene

Deatailed information for cohesin site CDBP00418647