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Basic information

CohesinDB ID: CDBP00418650

Locus: chr21-36916572-36919027

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE86191, GSE101921, ENCSR806UKK, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, CVI-hiPSC, Liver, Transformed-RPE1, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, MB157, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, THP-1, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM19238, HeLa, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 69% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.333

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 46%, "7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, HMG20A, ZNF660, SOX2, FOXA1, RXRB, KDM3A, TFAP4, THRB, ZC3H8, ZFP64, ZNF362, RUNX3, CHD7, ZBTB44, PRDM1, MXD4, ZNF189, SMARCE1, ZNF736, SFPQ, ZNF467, ZNF629, ELF1, ZNF121, TEAD1, KLF6, ZNF217, ESR1, RCOR2, ZNF561, CTCF, TCF12, JUN, EP300, BAF155, LMO1, MNT, SOX5, DMAP1, IRF4, DEK, ZNF528, SMC1, FOXA3, ZNF175, GATAD2A, PDX1, TFAP2C, RBPJ, MLX, GLIS1, GTF2F1, NANOG, CHD8, BRD1, POU2F2, BRD3, ZSCAN21, ZBTB17, ZBTB48, ZNF317, SRF, GATAD1, SAP130, ARID3A, HNF4G, ERG, HOXC5, ZNF341, MYC, ONECUT1, SMARCA4, ZNF2, HOMEZ, RAD21, EOMES, RXRA, NKX2-1, STAT3, APC, XRCC5, ZNF614, NKX3-1, MIER3, TERF2, ZNF639, NR2F6, DNMT3B, ZNF750, NR3C1, CEBPB, ESRRA, CREB1, EZH2, KLF8, ZNF652, GABPB1, ZKSCAN5, SPI1, TFE3, MIXL1, HBP1, ZNF257, IRF1, HDAC2, GATA2, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, SMARCA5, MRTFB, NFIL3, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, EZH2phosphoT487, SOX13, ZFX, SMAD3, ZNF770, ZNF654, TRIM22, SMARCC1, PRDM10, MYBL2, RARA, ZNF384, NOTCH1, ZBTB2, ZNF35, CREBBP, RUNX2, GATA4, OSR2, ZNF184, PBX4, ARNT, ZNF48, SMAD4, FOS, HMGXB4, SMARCB1, MED1, TEAD3, MYB, PIAS1, SMAD1, SETDB1, MBD1, MAFK, SP1, TFAP2A, USF1, HNF4A, BCL11A, IKZF5, REST, ASH2L, PHIP, FOXP1, PRDM6, SMC3, ELL2, STAG1, STAG2, SKI, ZNF283, PPARG, FOXA2, CREM, SS18, ZNF600, ZNF692, MIER2, ZSCAN16, GTF2B, FOXF1, CDK9, ZNF580, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, HIF1A, OTX2, GATA3, TAL1, MAX, ZNF143, KLF4, CEBPG, NR2F2, TCF7L2, NEUROG2, KDM5B, TP53, NFKB1, MYOD1, ELF3, BRD2, KAT8, PHF5A, ARID4B, AR, NFKBIZ, EGLN2, ZBTB42, RB1, ZBTB26, HSF1, BRD4, JUND, TBX2, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): SIM2,CHAF1B,CBR3,HLCS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 30

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159231, ENSG00000159259, ENSG00000159263, ENSG00000159267,

eachgene

Deatailed information for cohesin site CDBP00418650