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Basic information

CohesinDB ID: CDBP00418660

Locus: chr21-36939198-36940146

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 70% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.178

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 70%, "7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, HMG20A, ZNF660, SOX2, PATZ1, FOXA1, PBX2, UBTF, RXRB, ATF3, ZC3H8, ZFP64, HNRNPUL1, CTCFL, ZNF444, MXD4, ZNF189, CDX2, JMJD1C, KLF5, TEAD1, TRIM28, ELF1, ZNF121, NFE2L2, ESR1, PITX3, HDAC8, ZNF561, CTCF, TCF12, EP300, BAF155, ZBTB20, SOX5, DPF2, IRF4, RFX5, DEK, PRKDC, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, RBPJ, EED, TFAP2C, GLIS1, MLX, CHD8, ZSCAN5D, POU5F1, ZNF263, BRD3, MYCN, CDK7, CTBP1, ZNF317, ZNF778, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, SP4, TBP, ERG, HOXC5, ZBTB8A, MYC, RFX1, HOMEZ, RAD21, RXRA, NKX2-1, GABPA, XRCC5, NKX3-1, PRDM14, IKZF1, TEAD2, DNMT3B, RCOR1, NR3C1, CEBPB, CREB1, TBL1XR1, KLF8, GRHL2, FEZF1, EBF3, GABPB1, ZHX2, SPI1, HBP1, MIXL1, TFE3, KLF17, HDAC2, SSRP1, ZNF644, MXD3, FLI1, GTF3C5, DRAP1, MXI1, MRTFB, NFIL3, ZNF554, ETV5, RUNX1, THAP11, SMC1A, CBX1, HDAC1, NKX2-2, AFF4, ZFX, SOX13, SIN3A, SMAD3, ZNF654, ERG3, TRIM22, ZMIZ1, ZNF549, SMARCC1, CREBBP, ZBTB2, ZNF35, NOTCH1, RUNX2, CDK6, ARNT, ATF2, ZNF48, SMAD4, NFYA, HMBOX1, FOXM1, CDK8, HMGXB4, MED1, TEAD3, PIAS1, SMAD1, KLF9, MBD1, STAT5A, RBM22, SP1, BCL11A, HNF4A, IKZF5, REST, ATF7, ZHX1, ASH2L, HNRNPLL, CTBP2, SMC3, ELL2, STAG1, STAG2, MLLT1, ZNF816, SKI, PPARG, CBX3, MTA3, CREM, CHD2, MIER2, ZNF692, ZSCAN16, ZNF30, MAFF, WT1, ZNF574, MEF2C, CDK9, ZNF580, ZKSCAN1, KDM1A, YY1, RELA, SP140, HIF1A, SKIL, OTX2, TAL1, MAX, SPIB, ZNF143, CEBPG, SP7, NCOA3, NR2F2, KDM5B, TP53, BRD2, ELF3, KAT8, PHF5A, ARRB1, BHLHE40, PAX3-FOXO1, AR, TAF1, ARID4B, YAP1, ZNF324, EGLN2, RB1, HSF1, ZBTB26, JUND, ILF3, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): CHAF1B,SIM2,CBR3,KCNJ6,HLCS,TTC3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000159231, ENSG00000159259, ENSG00000159263, ENSG00000159267, ENSG00000182670, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418660