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Basic information

CohesinDB ID: CDBP00418666

Locus: chr21-36949217-36949518

Data sourse: GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 48%, "8_ZNF/Rpts": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, POU2F2, CHD8, CEBPA, MYCN, POU5F1, ZSCAN5D, SOX2, ZFX, HDAC1, XBP1, ZBTB17, DUX4, WT1, SRF, ZNF770, KDM1A, YY1, RELA, HDGF, NEUROD1, MYC, EOMES, SMARCA4, CHD7, TCF4, HIF1A, BHLHE22, OTX2, PAX5, TP63, SPIB, ZNF143, CDK8, GATA1, CBFA2T3, IKZF1, MAX, RCOR1, CEBPG, CEBPB, TEAD3, CEBPD, TRIM28, SCRT2, NEUROG2, KDM5B, LMO2, TP53, ZNF334, ZNF565, EBF3, CTCF, SPI1, AR, GATA6, PAX8, HDAC2, GATA2, TRIM24, SCRT1, BRD4, SMC3, AHR

Target gene symbol (double-evidenced CRMs): CHAF1B,HLCS,CBR3,SIM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159231, ENSG00000159259, ENSG00000159263, ENSG00000159267,

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Deatailed information for cohesin site CDBP00418666