Deatailed information for cohesin site CDBP00418672

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  • Basic information
  • CohesinDB ID: CDBP00418672
  • Locus: chr21-36964520-36968171
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE126634, ENCSR150EFU, GSE105028, GSE111537, GSE131606, ENCSR330ELC, GSE108869, GSE25021, GSE115602, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE143937, GSE93080, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE206145-NatGen2015, ENCSR198ZYJ, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE106870, GSE116344, ENCSR895JMI, GSE118494, ENCSR338DUC, GSE98367, ENCSR193NSH, GSE206145, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, ENCSR981FDC, ENCSR000BMY, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, GSE62063, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE131956, GSE110061, GSE129526, ENCSR676MJK, GSE111913, GSE155324, GSE38411, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR000ECS, GSE131577
  • Cell type: RH4, GM10847, GM2610, GM19240, HSPC, CVI-hiPSC, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, RT-112, GM19193, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HCAEC, Ramos, GM19238, OCI-AML-3, HAP1
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 41% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.389
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 94% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 25%, "2_TssAFlnk": 23%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, KDM3A, HDGF, THAP1, IKZF3, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, E4F1, ARID5B, SOX5, PAX8, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, TOP2A, ZNF263, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, TOP1, FOXK2, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ELF4, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, HCFC1, MXI1, RELB, EP400, RUNX1, HDAC1, CEBPA, REPIN1, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ELK1, ZBTB10, ATF2, ZNF354A, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, C11orf30, MBD1, IKZF5, ARID2, RBM25, AFF1, MBD2, ZNF337, ELL2, HMGB1, ETV4, NFATC3, CBX3, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, CREB3L1, NEUROD1, MAF1, PLAG1, KLF4, ZFP69B, BCL11B, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, SRSF4, ZNF596, HNRNPK, CDK2, ATF3, THRB, ZFP64, RUNX3, CBFB, ZNF273, ZSCAN4, TP63, MITF, ZNF467, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, CTCF, TAF3, MNT, ZBTB20, LMO1, DPF2, RYBP, IRF4, ZNF423, ZNF350, PDX1, TFAP2C, RBPJ, MLX, ZNF239, MTA2, ZBTB17, ZSCAN21, ZNF317, ZBTB48, NONO, SRF, DDX5, NBN, PHB2, TSHZ1, HOMEZ, ZNF2, KDM4A, FOXP2, RXRA, LEF1, MIER3, NR3C1, STAT5B, KMT2A, ZBTB11, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, ZNF146, SMARCA5, NFIL3, CC2D1A, THAP11, LDB1, SOX13, AFF4, ZNF770, ZNF513, ZMIZ1, ZNF792, SP3, ARNT, BACH1, ZNF48, HMBOX1, ZEB2, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, ZNF623, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, ZNF143, MTA1, AGO2, TP53, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, ZSCAN23, IRF9, ZNF468, PGR, FANCL, CBX5, SOX2, PATZ1, LEO1, UBTF, RING1B, TFAP4, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF524, KLF1, SOX9, SOX4, E2F6, TRIM24, ZNF808, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ELK4, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, SRSF3, EZH2, NFE2L1, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF490, ZNF76, ETV5, BCL6, SIN3A, ERG3, MYBL2, RARA, ZNF384, ZNF35, NFYC, TAF15, CREBBP, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, GTF3C2, ZNF22, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, ZNF44, ZNF692, GTF2B, ZNF318, FOXO3, RELA, TARDBP, ZNF282, SKIL, MAX, ZNF592, GFI1B, NR2F1, ZNF791, KDM5B, NEUROG2, TCF7L2, PKNOX1, MYOD1, T, AR, KMT2D, ZNF324, HEXIM1, ZNF280D, DMAP1, AHR, FOSL2, HMG20A, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, ZNF362, CTCFL, KLF14, MECOM, HDAC3, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, GMEB2, ARID3A, ASCL1, MIER1, ZNF341, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, ZNF639, JMJD6, FEZF1, TRPS1, HES1, TFE3, HBP1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, MAFG, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, NMYC, TWIST1, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, CDK6, NRF1, SUPT5H, FOS, CHD1, TGIF2, MED1, CEBPD, MYB, ZNF558, SCRT2, KDM6B, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, ZNF783, SKI, NELFA, ZNF283, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, ASXL1, SP140, HIF1A, OTX2, ZNF740, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, MEF2D, ZNF24
  • Target gene symbol (double-evidenced CRMs): VPS26C,HLCS,TTC3,DYRK1A
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 46
  • Number of somatic mutations (non-coding): 18
  • Related genes and loops
  • Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540,
  • Related loop: chr21:36938714-36940414~~chr21:36965300-36967660, chr21:36938850-36940337~~chr21:36965489-36966668, chr21:36950000-36975000~~chr21:37050000-37075000, chr21:36950000-36975000~~chr21:37075000-37100000, chr21:36950000-36975000~~chr21:37250000-37275000, chr21:36950000-36975000~~chr21:37350000-37375000, chr21:36950000-36975000~~chr21:37550000-37575000,
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