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Basic information

CohesinDB ID: CDBP00418675

Locus: chr21-36974936-36975856

Data sourse: GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE165895

Cell type: RPE, Fibroblast, HCT-116, K-562, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 54%, "5_TxWk": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, ZSCAN5C, XBP1, PATZ1, RBFOX2, PBX2, UBTF, LEO1, ZFHX2, HDGF, ATF3, INSM2, ZFP64, PRDM1, KLF14, ZNF189, SMARCE1, ZNF629, KLF5, ELF1, KLF10, ESR1, HDAC8, CTCF, JUN, EP300, E4F1, KLF1, GATA6, DPF2, E2F6, CREB3, SOX6, E2F1, ZNF175, PDX1, TFAP2C, GLIS1, MYCN, POU5F1, ID3, KDM4C, CTBP1, ZSCAN21, ZBTB17, ZBTB48, HINFP, NONO, ZNF134, SRF, NBN, ERG2, SP4, TBP, ZBTB21, ZNF341, ETS1, MYC, ZBTB8A, SMARCA4, TSHZ1, ARID1B, GABPA, IKZF1, RCOR1, HNRNPH1, ZNF639, ESRRA, CREB1, ZBTB11, KLF8, ZHX2, IRF1, KLF17, ZNF257, HDAC2, ZNF202, GATA2, ZNF644, ZNF554, ATF1, GTF2A2, MAFG, SMC1A, HDAC1, ZNF335, ZFX, ZFP37, ZNF770, ERG3, PRDM10, IRF2, RUNX2, OSR2, ZNF184, SP3, NRF1, BACH1, ARNT, ATF2, ZEB2, ZNF518A, NR2C1, ZNF10, SP2, FOS, ZNF584, ZEB1, DIDO1, ZNF558, SCRT2, KLF9, NCOA1, L3MBTL2, SETDB1, RBM22, SP1, BCL11A, NR4A1, REST, ATF7, HNRNPLL, AFF1, THRA, PHIP, ZNF623, SMC3, STAG1, MLLT1, PTTG1, ZNF394, KLF13, FOXA2, CBX3, MTA3, CREM, E2F8, ZNF600, ZNF692, WT1, ZNF574, ZBTB33, ZNF318, ZNF589, YY1, RELA, TARDBP, JUNB, ZNF148, SP140, ZFP36, SKIL, KLF15, MAX, ZNF449, GATA1, AGO2, PLAG1, ZNF592, SP7, ZKSCAN8, NR2F1, ZBTB6, PKNOX1, ZNF334, BRD2, AR, PTRF, ZBTB40, ZNF324, ZNF366, RB1, ZNF280D, RNF2, NCOR1, JUND, ILF3, BRD4, MAZ, ZSCAN23, IRF9, ZNF24, ZNF395, AHR

Target gene symbol (double-evidenced CRMs): VPS26C,HLCS,KCNJ6,TTC3,DYRK1A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418675