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Basic information

CohesinDB ID: CDBP00418678

Locus: chr21-36982411-36982979

Data sourse: GSE126634, ENCSR153HNT

Cell type: K-562, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 44%, "14_ReprPCWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, HDGF, ZBTB44, IKZF3, PAX5, TEAD1, ZNF121, LMO2, OCA2, ZNF561, SOX5, PAX8, DEK, ZNF528, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, BRD3, CTBP1, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, MXD3, FLI1, HCFC1, DRAP1, RELB, RUNX1, CEBPA, HDAC1, NKX2-2, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, TERF1, PIAS1, SMAD1, EVI1, MBD1, ARID2, IKZF5, RBM25, AFF1, NFATC3, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, SS18, WT1, MEF2C, JUNB, NEUROD1, ZFP36, BATF, MAF1, SPIB, PLAG1, KLF4, ZFP69B, BCL11B, ZBTB6, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, ILF3, FOSL1, ZNF660, XBP1, ZNF101, PBX2, ATF3, ZFP64, RUNX3, CBFB, ZSCAN4, TP63, MITF, ZNF467, JMJD1C, MAF, ELF1, SNAI2, CTCF, JUN, TAF3, ZBTB20, DPF2, RYBP, IRF4, ZNF423, ZNF280A, PDX1, RBPJ, TFAP2C, ZNF239, ZSCAN21, ZBTB17, MTA2, ZBTB48, SRF, DDX5, NBN, KDM4A, HOMEZ, ZNF2, RXRA, BATF3, NKX3-1, PRDM14, MIER3, TERF2, NR3C1, ESRRA, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, ZBTB14, ZNF146, SMARCA5, NFIL3, CC2D1A, THAP11, ZBTB24, LDB1, EZH2phosphoT487, SOX13, AFF4, ZNF770, SP3, ARNT, BACH1, DAXX, ZNF48, PRDM9, ZEB2, HMBOX1, NFYA, PBX3, ETV6, NCAPH2, ZNF10, HMGXB4, TEAD3, ZXDB, KLF9, USF1, BCL11A, SP1, ATF7, ASH2L, CTBP2, GLIS2, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, KLF7, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, CBX2, TP53, ZNF334, ZSCAN22, PHF5A, BRD2, KAT8, TBX21, RB1, TFIIIC, RNF2, IKZF2, JUND, BRD4, ZSCAN23, IRF9, PGR, SOX2, PATZ1, RING1B, UBTF, TFAP4, CHD7, ZNF444, ATF4, MXD4, ZNF189, MZF1, KLF6, NFE2L2, ZNF217, ESR1, ZNF524, KLF1, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, HIC1, TBP, HOXC5, OGG1, ETS1, MYC, KLF12, NKX2-1, GABPA, STAT3, IKZF1, EZH2, ZNF652, PHF8, SPI1, HDAC2, GATAD2B, ZNF777, NFYB, ZNF76, ETV5, BCL6, SIN3A, ZFP37, ERG3, RARA, ZNF384, NFYC, ZNF35, TAF15, HMGB2, SMAD4, CDK8, ZEB1, ZMYM3, NCOA1, ZNF22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, NR2F1, KDM5B, PKNOX1, AR, ZNF324, HEXIM1, AHR, DMAP1, FOSL2, ZNF391, HMG20A, MEIS2, SUZ12, RBFOX2, ZFHX2, LYL1, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, ZNF629, KLF5, BCLAF1, ETV1, RCOR2, USF2, TCF12, EP300, BAF155, GATA6, GLI4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ARID3A, ZNF300, ZNF341, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF664, TFE3, IRF1, ZGPAT, MRTFB, ATF1, SMC1A, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, TWIST1, PRPF4, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, SMAD2, PBX4, FOS, CHD1, MED1, CEBPD, MYB, KDM6B, SCRT2, ZNF3, L3MBTL2, KLF16, NIPBL, ZBTB7A, PHIP, TCF3, SKI, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF610, SP140, HIF1A, OTX2, ZNF449, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, NFKBIZ, BHLHE40, TAF1, ZBTB42, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): KCNJ6,DYRK1A,TTC3,HLCS,VPS26C

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418678