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Basic information

CohesinDB ID: CDBP00418682

Locus: chr21-36987033-36987211

Data sourse: GSE105028, ENCSR054FKH, GSE72082, ENCSR167MTG

Cell type: Hep-G2, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 56%, "5_TxWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF675, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, MED26, HDAC8, ZNF561, E4F1, ARID5B, ZNF75A, SOX5, PYGO2, PAX8, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, ZNF263, TOP2A, CTBP1, ERF, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CD74, DACH1, CEBPB, HNRNPL, RBM34, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, ZNF785, NR2C2, HCFC1, MXI1, RELB, EP400, RUNX1, CEBPA, NKX2-2, ZNF707, HDAC1, REPIN1, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, MBD1, GSPT2, IKZF5, ARID2, RBM25, ZSCAN31, AFF1, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, PLAG1, ZFP69B, BCL11B, KLF4, ZNF530, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ZNF660, HNF1A, XBP1, KDM4B, PBX2, SRSF4, ZNF596, HNRNPK, CDK2, THRB, ATF3, ZFP64, HNRNPUL1, RUNX3, ZNF532, CBFB, ZNF273, ZSCAN4, TP63, MITF, ZNF467, MAF, INTS11, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, TAF3, JUN, L3MBTL4, ZBTB20, MNT, LMO1, DPF2, RYBP, IRF4, ZNF423, PDX1, RBPJ, MLX, TFAP2C, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, CHD4, PBX1, ZNF2, HOMEZ, KDM4A, FOXP2, TSHZ1, RXRA, NKX3-1, PRDM14, MIER3, TEAD2, TERF2, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, ZNF565, EBF3, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, ZBTB24, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, DAXX, ARNT, NFIB, BACH1, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, ZXDB, ZNF680, U2AF1, TAF7, KLF9, ZBTB18, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, ZNF548, CTBP2, GLIS2, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KLF7, KDM1A, ZNF19, ZNF441, BRG1, ISL1, ZIC2, PCGF1, GATA3, KLF15, TAL1, ZNF143, AGO2, MTA1, TP53, ZSCAN22, NFKB1, PHF5A, BRD2, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, CUX1, ZSCAN23, TBX2, PGR, FANCL, CBX5, SOX2, PATZ1, RING1B, UBTF, TFAP4, SIN3B, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, TP73, ZNF524, KLF1, ZNF695, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, KDM4C, ZSCAN5A, ELK4, ZMYND8, HIC1, ERG2, SP4, TBP, HOXC5, ETS1, MYC, ARID1B, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, ZNF554, NFYB, NCOA2, ETV5, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, MYBL2, RARA, ZNF384, ZNF35, NFYC, TAF15, CREBBP, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZNF264, ZMYM3, NCOA1, GTF3C2, RBM22, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, ZNF816, PPARG, TBL1X, ZNF692, GTF2B, JDP2, ZNF574, TCF7, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, T, AR, ZBTB16, ZNF324, RBAK, HEXIM1, DMAP1, AHR, FOSL2, ZNF391, HMG20A, LCORL, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, SFMBT1, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, ZFP91, TCF12, EP300, BAF155, NUTM1, PRDM4, GLI4, CREB3, SOX6, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, ID3, RUNX1T1, GATAD1, ARID3A, ASCL1, MIER1, ZNF341, USP7, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF750, FEZF1, TFE3, HBP1, IRF1, GTF3C5, SREBF1, ZGPAT, NAB2, MRTFB, ZC3H11A, ATF1, PTBP1, CBX1, SMC1A, SIRT6, FIP1L1, ZFX, ZNF335, SMAD3, PCBP2, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, CDK6, PBX4, NRF1, CHD1, FOS, SUPT5H, MED1, KDM6B, MYB, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, NELFA, ZNF283, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF83, ZNF512, ZNF687, ZNF213, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): KCNJ6,TTC3,VPS26C,DYRK1A,HLCS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418682