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Basic information

CohesinDB ID: CDBP00418688

Locus: chr21-36994195-36995191

Data sourse: ENCSR000BLD, GSE67783, GSE86191, GSE110061, GSE116868, GSE129526, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, GSE206145, ENCSR153HNT, GSE131606, GSE50893, GSE97394

Cell type: RPE, H1-hESC, Fibroblast, HCT-116, MB157, GM2610, DKO, HUES64, K-562, HSPC, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 27%, "15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, RING1B, ATF3, CTCFL, CHD7, PAX5, TP63, MAF, TRIM28, SNAI2, ESR1, CTCF, TCF12, EP300, RYBP, E2F6, TEAD4, GTF2F1, TFAP2C, NANOG, MYCN, POU5F1, ZBTB48, STAT1, ZNF563, SP4, TBP, OGG1, ETS1, MYC, KDM4A, RAD21, GABPA, STAT3, XRCC5, IKZF1, ZNF667, NR3C1, CEBPB, KMT2A, CREB1, EZH2, BMPR1A, PHF8, ZHX2, SPI1, HDAC2, GATAD2B, FLI1, HCFC1, RUNX1, BCL6, EZH2phosphoT487, ZFX, SMAD3, TET2, ATF2, CHD1, ZNF3, SP1, REST, ASH2L, CTBP2, BCOR, AATF, SMC3, STAG1, TRP47, AGO1, FOXA2, RBBP5, CHD2, ZBTB33, BCL3, KDM1A, RELA, SP140, PCGF1, GATA3, MAF1, MAX, GATA1, ZNF143, BCL11B, KDM5B, RBM14, TBX21, AR, TAF1, HEXIM1, HSF1, BRD4, JUND, AHR

Target gene symbol (double-evidenced CRMs): DYRK1A,TTC3,VPS26C,KCNJ6,HLCS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542,

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Deatailed information for cohesin site CDBP00418688