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Basic information

CohesinDB ID: CDBP00418694

Locus: chr21-37004998-37009161

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE25021, GSE131606, GSE67783, ENCSR000BKV, GSE86191, GSE206145-NatGen2015, ENCSR198ZYJ, GSE130135, ENCSR703TNG, GSE116344, GSE118494, ENCSR338DUC, GSE206145, ENCSR167MTG, GSE111913, ENCSR153HNT, GSE50893

Cell type: RH4, H9-hESC, RPE, Fibroblast, GM2255, IMR-90, K-562, DKO, H1-hESC, GM18951, MB157, SK-N-SH, RT-112, MCF-7, HCT-116, HEK293T, Hep-G2, Neurons-H1, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.789

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: False Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "13_ReprPC": 25%, "14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF616, FOXA1, RXRB, MLL4, KDM3A, HDGF, MEN1, ZBTB44, ZNF322, MORC2, PAX5, ZNF320, TEAD1, ZNF121, LMO2, OCA2, PITX3, ZNF561, SOX5, DEK, E2F4, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, BRD3, CTBP1, ERF, DUX4, STAT1, ZNF563, SAP130, ERG, ZBTB8A, EZH1, SMARCA4, RFX1, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, HCFC1, MXI1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, IRF3, REPIN1, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, TFDP1, ATF2, SMARCB1, ZNF331, PIAS1, SMAD1, C11orf30, MBD1, IKZF5, ARID2, ZSCAN31, ZNF605, MBD2, ELL2, HMGB1, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, ZSCAN16, WT1, MEF2C, NEUROD1, ZFP36, BATF, MAF1, SPIB, ZNF333, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, RBM14, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, SCRT1, ILF3, ZNF316, ZNF660, XBP1, HNF1A, KDM4B, PBX2, HNRNPK, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, JMJD1C, MAF, ELF1, RBM39, SNAI2, JUN, CTCF, TAF3, ZBTB20, LMO1, RYBP, DPF2, IRF4, ZNF423, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZNF239, MTA2, ZSCAN21, ZBTB48, ZBTB17, ZNF317, NONO, SRF, DDX5, NBN, ZNF25, ONECUT1, KDM4A, ZNF2, HOMEZ, FOXP2, RXRA, NKX3-1, MIER3, HNRNPH1, TERF2, VDR, NR3C1, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, ZBTB14, ZNF146, SMARCA5, NFIL3, THAP11, ZNF585A, EZH2phosphoT487, LDB1, SOX13, AFF4, ZMIZ1, SP3, ARNT, BACH1, ZNF48, ZEB2, NFYA, HMBOX1, PBX3, NCAPH2, MAFB, ZNF10, HMGXB4, TEAD3, ZXDB, ZNF680, KLF9, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, PCGF2, CTBP2, GLIS2, PRDM6, ZNF623, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, KDM1A, ZNF502, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, ZNF143, AGO2, MTA1, ZNF768, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, ZNF468, PGR, SOX2, PATZ1, RING1B, UBTF, TFAP4, SIN3B, SETX, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, KLF1, ZNF695, SOX9, ZNF260, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, ZNF24, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, DNMT3B, EZH2, ZNF652, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, GATAD2B, ZNF76, ZNF554, NFYB, ETV5, BCL6, SIN3A, ZBTB12, ERG3, RARA, ZNF384, CREBBP, ZNF35, TAF15, NFYC, SMAD4, ZNF518A, CDK8, ZEB1, ZNF264, ZNF22, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, RELA, TARDBP, SKIL, MAX, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, AR, ZNF445, YAP1, ZNF324, HEXIM1, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, SUZ12, RBFOX2, ZNF28, ZFHX2, CTCFL, PRDM1, KLF14, ZNF736, ZNF629, ZNF506, KLF5, TRIM28, BCLAF1, RCOR2, HNF1B, USF2, TCF12, EP300, BAF155, GATA6, SOX6, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, ZNF649, GATAD1, ARID3A, ZNF300, ASCL1, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF667, ZNF639, JMJD6, HBP1, TFE3, IRF1, ZGPAT, ZNF418, ZNF766, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, CDK6, NRF1, PBX4, CHD1, FOS, MED1, KDM6B, CEBPD, SCRT2, MYB, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, PHIP, TCF3, TAF2, SKI, ZNF283, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF610, SP140, HIF1A, OTX2, ZNF519, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, ZNF687, ZNF213, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): HLCS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 56

Number of somatic mutations (non-coding): 19

Related genes and loops

Related gene: ENSG00000159267,

eachgene

Deatailed information for cohesin site CDBP00418694