- Basic information
- CohesinDB ID: CDBP00418719
- Locus: chr21-37059694-37061303
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Data sourse: ENCSR000BLD, GSE104888, GSE72082, ENCSR000BSB, GSE126634, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, GSE165895, ENCSR000EFJ, GSE143937, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, ENCSR198ZYJ, GSE130135, ENCSR703TNG, GSE116344, GSE94872, ENCSR000EEG, ENCSR338DUC, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE129526, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, ENCSR000ECS
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Cell type: RH4, HuCC-T1, RPE, HMEC, Fibroblast, HeLa-S3, IMR-90, K-562, HFFc6, DKO, H1-hESC, SK-N-SH, RT-112, HAP1, HUES64, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 23% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.733
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 34%,
"7_Enh": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, ZSCAN5C, SOX2, MEIS2, XBP1, FOXA1, RXRB, PBX2, ZNF28, PRDM1, MZF1, ZNF467, JMJD1C, TRIM28, LMO2, ESR1, OCA2, ZNF77, PITX3, MLL, USF2, CTCF, TCF12, EP300, GATA6, SOX5, TRIM24, TEAD4, FOXA3, GATAD2A, TFAP2C, RBPJ, POU2F2, NANOG, MYCN, POU5F1, RUNX1T1, TOP2A, DUX4, ZSCAN5A, ZBTB48, SAP130, ZNF485, ZNF300, ERG, MYC, RAD21, GRHL3, RXRA, RCOR1, NR2F6, NR3C1, ESRRA, CEBPB, KMT2A, CREB1, EZH2, ZNF652, EBF3, SPI1, MIXL1, HDAC2, GATA2, ZNF644, FLI1, NFIL3, ETV5, CC2D1A, RUNX1, CBX1, BCL6, CEBPA, SOX13, ZFX, SP5, SMARCC1, RARA, CDK6, SOX11, PRDM9, CDK8, TEAD3, MYB, ZNF680, L3MBTL2, SETDB1, ZNF22, BCL11A, PHIP, TCF3, FOXP1, SMC3, STAG1, ZNF316, FOXA2, CHD2, MIER2, ZNF30, WT1, MEF2C, HOXB13, KDM1A, YY1, RELA, CHAMP1, ISL1, SP140, HIF1A, GATA3, TAL1, MAX, MAF1, NRIP1, GATA1, HAND2, KLF4, NR2F2, ZNF334, PHOX2B, AR, PAX3-FOXO1, EGLN2, NOTCH3, BRD4, MAZ, TBX2, AHR
- Target gene symbol (double-evidenced CRMs): VPS26C,SIM2,DYRK1A,HLCS
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 3
- Number of somatic mutations (non-coding): 3
- Related genes and loops