- Basic information
- CohesinDB ID: CDBP00418720
- Locus: chr21-37061566-37062938
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Data sourse: ENCSR000EEG, GSE67783, GSE86191, ENCSR404BPV, GSE206145-NatGen2015, ENCSR198ZYJ
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Cell type: Fibroblast, HCT-116, Hep-G2, Neurons-H1, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 56%,
"15_Quies": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, ZBTB44, IKZF3, ZNF320, ZNF586, TEAD1, ZNF121, OCA2, MED26, PITX3, ZNF561, SOX5, DEK, ZNF528, RFX3, GATAD2A, NANOG, POU5F1, ZNF263, CTBP1, ZNF134, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RFX1, FOXK2, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, RUNX1, CEBPA, NKX2-2, SP5, SMARCC1, PRDM10, ZNF549, SMARCB1, TERF1, ZNF331, NR1H2, IKZF5, ARID2, ELL2, CBFA2T2, MEF2B, CBX3, CHD2, SS18, PAF1, WT1, NEUROD1, JUNB, TCF4, PLAG1, KLF4, MED, EGR2, ELF3, ARID4B, EGLN2, ZBTB26, NCOR1, FOSL1, ZNF660, XBP1, PBX2, ATF3, ZC3H8, ZFP64, RUNX3, CBFB, ZNF273, TP63, MITF, MYOG, JMJD1C, MAF, KLF10, CTCF, JUN, MNT, DPF2, IRF4, ZNF423, PDX1, RBPJ, MLX, TFAP2C, ZSCAN21, ZBTB17, ZNF317, ZBTB48, SRF, PBX1, ZNF329, ZNF2, HOMEZ, TSHZ1, FOXP2, NKX3-1, MIER3, NR3C1, KMT2A, CCAR2, FOXK1, TBL1XR1, KLF8, GRHL2, EBF3, NFIL3, THAP11, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZNF770, ZNF18, ARNT, BACH1, DAXX, ZNF48, ZEB2, PBX3, MAFB, ZNF10, HMGXB4, ICE2, TEAD3, ZXDB, ZNF680, KLF9, ZBTB18, SP1, BCL11A, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, STAG1, STAG2, ZNF394, EBF1, MEIS1, MAFF, ZNF580, KDM1A, ZNF222, ZIC2, GATA3, TAL1, ZNF143, AGO2, TP53, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, BRD4, JUND, CUX1, ZSCAN23, SOX2, PATZ1, TFAP4, SIN3B, CHD7, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, TP73, ZNF695, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZSCAN5A, ERG2, TBP, HNF4G, HOXC5, ETS1, MYC, ZNF671, ARID1B, NKX2-1, STAT3, IKZF1, EZH2, ZNF652, MRTFA, SPI1, HDAC2, ZNF554, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF384, ZNF35, CREBBP, ZNF133, NFYC, SMAD4, CDK8, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, BCOR, FOXP1, NCOR2, ZNF34, ZNF816, PPARG, TBL1X, ZNF692, ZNF30, ZNF574, RELA, MAX, NEUROG2, TCF7L2, ZNF547, MYOD1, ZNF12, AR, ZNF324, AHR, DMAP1, FOSL2, HMG20A, LCORL, ZSCAN5C, E2F7, ZFHX2, INSM2, CTCFL, PRDM1, CDX2, ZNF629, TRIM28, RCOR2, USF2, TCF12, EP300, BAF155, E2F1, TEAD4, FOXA3, ZNF175, EED, CHD8, MYCN, GATAD1, ARID3A, ASCL1, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, ZNF639, ARNTL, ZNF93, FEZF1, TFE3, IRF1, SREBF1, ZGPAT, MRTFB, MYF5, SMC1A, CBX1, ZFX, SMAD3, TWIST1, IRF2, NOTCH1, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, PBX4, NRF1, FOS, MED1, ZNF558, MYB, SCRT2, ZNF3, SETDB1, NIPBL, PHIP, TCF3, SKI, FOXA2, RBBP5, ZNF600, MIER2, FOXF1, ZBTB33, HOXB13, YY1, HIF1A, OTX2, ZNF519, ZNF449, CEBPG, SP7, NR2F2, NFKBIZ, BHLHE40, TAF1, ZBTB42, MYNN, CLOCK, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): SIM2,VPS26C,DYRK1A,HLCS
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 3
- Number of somatic mutations (non-coding): 3
- Related genes and loops