Deatailed information for cohesin site CDBP00418723
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- Basic information
- CohesinDB ID: CDBP00418723
- Locus: chr21-37070631-37076219
- Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE126634, ENCSR150EFU, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE62063, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE143937, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE130135, ENCSR703TNG, GSE106870, GSE116344, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR807WAC, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE131956, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE38411
- Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, B-cell, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, RT-112, HAP1, GM19099, Macrophage, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, Neutrophil, GM18951
- DNA Sequence of binding site: UCSC hg38
- Cohesin category
- Peak occupancy ratio: 42% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.389
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
- CTCF binding site: CTCF CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
- Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
- Compartment: 90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"2_TssAFlnk": 24%,
"1_TssA": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2). - Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, SFPQ, TEAD1, SNAPC1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, POU2F1, E4F1, ARID5B, SOX5, PAX8, ZNF407, DEK, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, BRD3, ZNF263, TOP2A, POU5F1, CTBP1, DUX4, STAT1, ZNF134, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CD74, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, ZNF785, MXI1, NR2C2, HCFC1, RELB, EP400, RUVBL2, RUNX1, CEBPA, NKX2-2, HDAC1, ZNF707, PALB2, REPIN1, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, GSPT2, IKZF5, ARID2, RBM25, AFF1, MBD2, ELL2, HMGB1, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, NFATC1, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, ZFP69B, KLF4, BCL11B, ZNF281, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, PBX2, HNRNPK, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, CBFB, DPF1, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, MYOG, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, ZNF624, FUS, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF423, RBPJ, TFAP2C, MLX, ZNF239, MTA2, ZBTB17, ZSCAN21, ZBTB48, NONO, SRF, NBN, ONECUT1, KDM4A, HOMEZ, ZNF2, FOXP2, TSHZ1, ZKSCAN2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, KDM5A, ZBTB14, SSRP1, ZNF146, SMARCA5, NFIL3, THAP11, EZH2phosphoT487, AFF4, SOX13, POU4F2, ZNF770, ZNF513, ZMIZ1, ZNF18, ZNF792, SP3, ARNT, DAXX, BACH1, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, TFAP2A, SP1, NKX2-5, ZNF479, ATF7, ASH2L, CTBP2, PCGF2, GLIS2, SMC3, MLLT1, STAG1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, KLF7, KDM1A, ZKSCAN1, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZSCAN22, NFKB1, PHOX2B, PHF5A, BRD2, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, SMAD4.1D12, TBX2, ZNF468, PGR, SOX2, PATZ1, SNAPC4, LEO1, UBTF, RING1B, TFAP4, SIN3B, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, ZNF217, ESR1, SAP30, ZNF524, KLF1, ZNF260, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ELK4, ERG2, SP4, HIC1, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, ZNF182, GATAD2B, NCOA2, ZNF76, NFYB, ETV5, BCL6, SIN3A, ZFP37, ERG3, MEF2A, CREBBP, ZNF35, RARA, NFYC, TAF15, ZNF169, ZNF384, SMAD4, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, SREBF2, ZNF22, RBM22, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, JDP2, TCF7, YY2, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF223, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, NEUROG2, ZNF791, PKNOX1, RUVBL1, MYOD1, AR, KMT2D, ZBTB16, ZNF324, HEXIM1, ZNF280D, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, ZNF90, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, HDAC3, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, GMEB2, ARID3A, ZNF585B, ASCL1, MIER1, ZNF341, EOMES, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, TRPS1, TFE3, ZNF664, HBP1, IRF1, ZGPAT, NAB2, ZNF418, MRTFB, ZIM3, MYF5, ATF1, PTBP1, CBX1, SMC1A, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, NMYC, TWIST1, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, GATA4, OSR2, GR, ZNF184, CDK6, PBX4, NRF1, SUPT5H, CHD1, FOS, MED1, ZNF7, KDM6B, MYB, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF449, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF837, ZNF843, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): VPS26C,CHAF1B,TTC3,SIM2,DYRK1A,HLCS
- Function elements
- Human SNPs: Height
- Number of somatic mutations (coding): 291
- Number of somatic mutations (non-coding): 66
- Related genes and loops
- Related gene: ENSG00000159259, ENSG00000159263, ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540,
- Related loop: chr21:34350000-34375000~~chr21:37050000-37075000, chr21:36400000-36425000~~chr21:37075000-37100000, chr21:36725000-36750000~~chr21:37050000-37075000, chr21:36950000-36975000~~chr21:37050000-37075000, chr21:36950000-36975000~~chr21:37075000-37100000, chr21:36975000-37000000~~chr21:37075000-37100000, chr21:36976280-36978448~~chr21:37078697-37080394, chr21:36976416-36978177~~chr21:37079107-37080371, chr21:36989121-36991424~~chr21:37071179-37074846, chr21:36999877-37001750~~chr21:37078770-37080416, chr21:36999885-37001435~~chr21:37078647-37080436, chr21:36999930-37001432~~chr21:37078697-37080394, chr21:37050000-37075000~~chr21:37250000-37275000, chr21:37050000-37075000~~chr21:37525000-37550000, chr21:37078878-37080096~~chr21:37582024-37583384,
Tools:
- Assay
