- Basic information
- CohesinDB ID: CDBP00418726
- Locus: chr21-37079061-37080047
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Data sourse: ENCSR000BLD, ShirahigeLab-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, GSE93080, ENCSR000DZP, GSE143937, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, ShirahigeLab-NatGen2015, GSE120943, ENCSR703TNG, GSE145327, ENCSR000EEG, GSE98367, ENCSR000BLS, ShirahigeLab, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS, GSE131577
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Cell type: MDM, GM10847, GM19240, Liver, HuCC-T1, H9-hESC, GM2630, Fibroblast, GM12890, HeLa-S3, GM2255, K-562, GM18486, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, GM12878, GM12891, SK-N-SH, GM19239, RT-112, GM19193, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, HCAEC, GM19238, HeLa, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 25% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.556
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 45%,
"5_TxWk": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: HMG20A, FOXA1, HDGF, MEN1, ZNF362, ZNF444, ATF4, SMARCE1, PAX5, JMJD1C, TRIM28, ZNF26, ESR1, CTCF, TCF12, MNT, DPF2, SMC1, GATAD2A, POU5F1, TOP2A, ZSCAN21, MTA2, DUX4, ZBTB48, SRF, NBN, ARID3A, BAHD1, MIER1, OGG1, MYC, SMARCA4, ARID1B, HOMEZ, RAD21, DNMT1, IKZF1, MIER3, RCOR1, ZNF639, NR3C1, CEBPB, SPI1, MIXL1, ZNF664, TFE3, HDAC2, GATA2, SMARCA5, ZNF766, CC2D1A, RUNX1, BCL6, SMC1A, HDAC1, CEBPA, ZNF770, TRIM22, CREBBP, ZNF384, ZBTB2, ZNF184, ARNT, ZEB2, HMBOX1, SUPT5H, CDK8, ZNF558, MYB, CEBPD, ZMYM3, C11orf30, NCOA1, SETDB1, BCL11A, NR4A1, ASH2L, BCOR, SMC3, MLLT1, MEF2B, PPARG, E2F8, ZBTB33, CDK9, ZNF318, KDM1A, OTX2, TAL1, GATA1, SP7, ZNF512, PKNOX1, PHOX2B, ELF3, PHF5A, ZFP28, ZBTB40, ZNF324, HSF1, RNF2, NCOR1, BRD4, ZNF24, ZNF316
- Target gene symbol (double-evidenced CRMs): TTC3,CHAF1B,HLCS
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 12
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000159259,
ENSG00000159267,
ENSG00000182670,
- Related loop:
chr21:34350000-34375000~~chr21:37050000-37075000,
chr21:36400000-36425000~~chr21:37075000-37100000,
chr21:36725000-36750000~~chr21:37050000-37075000,
chr21:36950000-36975000~~chr21:37050000-37075000,
chr21:36950000-36975000~~chr21:37075000-37100000,
chr21:36975000-37000000~~chr21:37075000-37100000,
chr21:36976280-36978448~~chr21:37078697-37080394,
chr21:36976416-36978177~~chr21:37079107-37080371,
chr21:36989121-36991424~~chr21:37071179-37074846,
chr21:36999877-37001750~~chr21:37078770-37080416,
chr21:36999885-37001435~~chr21:37078647-37080436,
chr21:36999930-37001432~~chr21:37078697-37080394,
chr21:37050000-37075000~~chr21:37250000-37275000,
chr21:37050000-37075000~~chr21:37525000-37550000,
chr21:37078878-37080096~~chr21:37582024-37583384,