Deatailed information for cohesin site CDBP00418731

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  • Basic information
  • CohesinDB ID: CDBP00418731
  • Locus: chr21-37086511-37087720
  • Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE93080, GSE101921, ENCSR806UKK, GSE51234, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, ENCSR895JMI, ENCSR000EEG, ENCSR247LSH, GSE105004, ENCSR676MJK, ENCSR054FKH, ENCSR748MVX, ENCSR000ECS, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, H1-hESC, GM18951, SNYDER, GM12878, GM12891, SK-N-SH, GM19239, HeLa-Tet-On, THP-1, GM19099, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, GM19238, HeLa, TC-71, OCI-AML-3, HAP1
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 51% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.489
  • Subunit: SA1,Rad21,SMC1,SA2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 90% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 59%, "15_Quies": 16%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOSL1, ZSCAN5C, MEIS2, XBP1, PATZ1, FOXA1, PBX2, HDGF, ATF3, PRDM1, ATF4, SMARCE1, ZSCAN4, MITF, ZNF736, ZNF629, TRIM28, NFE2L2, ESR1, CTCF, JUN, MNT, ZNF33A, DPF2, SOX6, DDX20, ZNF528, SMC1, TEAD4, PDX1, EHMT2, CHD8, ZNF778, ZSCAN21, ZBTB17, DUX4, ZNF317, ASH1L, SRF, NBN, ARID3A, HOXC5, USP7, ZBTB8A, SMARCC2, SMARCA4, ARID1B, RAD21, GRHL3, STAT3, XRCC5, NKX3-1, NFE2, LEF1, ZNF639, CEBPB, CREB1, FEZF1, HES1, SPI1, HDAC2, FLI1, SMARCA5, MRTFB, ATF1, RUNX1, MAFG, SMC1A, HDAC1, NKX2-2, ZNF534, SMAD3, ZNF770, ZNF654, PRDM10, ZBTB2, BRD9, RUNX2, GATA4, OSR2, ZNF184, ARNT, BACH1, NRF1, ZEB2, PBX3, MAFB, FOS, GMEB1, ZXDB, SCRT2, ZNF3, C11orf30, RBM22, USF1, MAFK, REST, PHIP, PRDM6, SMC3, STAG1, MLLT1, PAF1, NFATC1, ZNF600, ZNF692, MAFF, WT1, ZBTB33, HOXB13, BCL3, ZFP36, HIF1A, OTX2, MAX, ZNF449, MTA1, SP7, TP53, PKNOX1, PHOX2B, ELF3, BHLHE40, ZBTB40, ZNF324, ZNF366, SCRT1, BRD4, JUND, ILF3, ZSCAN23, ZNF24, ZNF316, FOSL2
  • Target gene symbol (double-evidenced CRMs): TTC3,HLCS,CHAF1B
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 160
  • Number of somatic mutations (non-coding): 32
  • Related genes and loops
  • Related gene: ENSG00000159259, ENSG00000159267, ENSG00000182670,
  • Related loop: chr21:36400000-36425000~~chr21:37075000-37100000, chr21:36938850-36940337~~chr21:37086674-37088107, chr21:36950000-36975000~~chr21:37075000-37100000, chr21:36975000-37000000~~chr21:37075000-37100000, chr21:36976114-36978430~~chr21:37086465-37088179, chr21:36976280-36978448~~chr21:37086131-37087976, chr21:36976394-36978416~~chr21:37086094-37088173, chr21:36976402-36978434~~chr21:37086106-37088263, chr21:36976404-36978374~~chr21:37086393-37088124, chr21:36976407-36978411~~chr21:37086055-37088195, chr21:36976420-36978417~~chr21:37086403-37088182, chr21:36976426-36978435~~chr21:37086473-37087963, chr21:36976427-36978248~~chr21:37086150-37088199, chr21:36976430-36978401~~chr21:37086077-37088227, chr21:36976435-36978463~~chr21:37086055-37088213, chr21:36989316-36991217~~chr21:37086306-37088100, chr21:36999934-37001381~~chr21:37086150-37088199,
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