- Basic information
- CohesinDB ID: CDBP00418755
- Locus: chr21-37166246-37167761
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE93080, GSE67783, GSE86191, GSE101921, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, THP-1, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 51% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.333
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"4_Tx": 56%,
"5_TxWk": 39%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: BRD4, FOSL1, FOXP1
- Target gene symbol (double-evidenced CRMs): VPS26C,DYRK1A,KCNJ6,TTC3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 168
- Number of somatic mutations (non-coding): 56
- Related genes and loops
- Related gene:
ENSG00000182670,
ENSG00000157538,
ENSG00000157540,
ENSG00000157542,
- Related loop:
chr21:33500000-33525000~~chr21:37150000-37175000,
chr21:37150000-37175000~~chr21:37250000-37275000,
chr21:37150000-37175000~~chr21:37275000-37300000,
chr21:37150000-37175000~~chr21:37350000-37375000,
chr21:37150000-37175000~~chr21:37375000-37400000,
chr21:37150000-37175000~~chr21:37450000-37475000,
chr21:37150000-37175000~~chr21:37500000-37525000,
chr21:37150000-37175000~~chr21:37575000-37600000,
chr21:37150000-37175000~~chr21:37625000-37650000,
chr21:37150000-37175000~~chr21:37650000-37675000,
chr21:37150000-37175000~~chr21:37900000-37925000,
chr21:37150000-37175000~~chr21:38150000-38175000,
chr21:37150000-37175000~~chr21:38325000-38350000,
chr21:37150000-37175000~~chr21:38350000-38375000,
chr21:37165903-37167741~~chr21:37711396-37713035,
chr21:37165914-37167790~~chr21:37581870-37583744,
chr21:37165919-37167804~~chr21:37641816-37643880,
chr21:37165919-37167819~~chr21:37641580-37643713,
chr21:37165924-37167794~~chr21:37581806-37583572,
chr21:37165928-37167803~~chr21:37581799-37583709,
chr21:37165939-37167680~~chr21:37581819-37583687,
chr21:37165941-37167805~~chr21:37641570-37643772,
chr21:37165948-37167801~~chr21:37581734-37583636,
chr21:37165963-37167815~~chr21:37581749-37583648,
chr21:37165963-37167815~~chr21:37641599-37643616,
chr21:37166002-37167735~~chr21:37641416-37644157,
chr21:37166095-37167716~~chr21:37496458-37497998,
chr21:37166121-37167634~~chr21:37462553-37463976,
chr21:37166201-37167778~~chr21:37581833-37583520,
chr21:37166297-37167797~~chr21:37563454-37566884,