- Basic information
- CohesinDB ID: CDBP00418764
- Locus: chr21-37194982-37195379
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Data sourse: GSE206145-NatGen2015, GSE67783, GSE86191
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Cell type: Fibroblast, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SA1,Rad21,SA2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 73%,
"5_TxWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, SOX2, NME2, HNF1A, XBP1, FOXA1, BMI1, NFIC, ATF3, CHD7, ZNF532, MITF, ZNF467, ELF1, TRIM28, ESR1, HNF1B, OCA2, CTCF, TCF12, NUTM1, GATA6, DPF2, E2F1, TFAP2C, GLIS1, POU2F2, CHD8, NANOG, ZSCAN5D, MYCN, POU5F1, RUNX1T1, CDK7, BRD1, MTA2, ZBTB48, DUX4, NBN, ARID3A, TBP, ZNF341, MYC, SMARCA4, EOMES, RAD21, GRHL3, GABPA, NKX3-1, PRDM14, IKZF1, NR3C1, EZH2, GRHL2, SPI1, IRF1, GATAD2B, MXD3, FLI1, RELB, NCOA2, PTBP1, RUNX1, SMC1A, NKX2-2, ZFX, ZNF534, TET2, ERG3, TRIM22, IRF2, ZNF384, NOTCH1, GATA4, ARNT, CBFA2T3, SUPT5H, CHD1, MED1, ZEB1, SMAD1, RBM22, USF1, SP1, BCL11A, REST, ATF7, BCOR, FOXP1, SMC3, MLLT1, STAG1, NFATC3, TRP47, CBFA2T2, TBL1X, RBBP5, PAF1, E2F8, GTF2B, WT1, YY1, RELA, TARDBP, SP140, ZIC2, SKIL, HIF1A, OTX2, MAX, ZNF143, AGO2, KLF4, NCOA3, NR2F1, KDM5B, NFKB1, PHOX2B, ELF3, TBX21, BHLHE40, AR, IKZF2, BRD4, NOTCH3, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): KCNJ6,TTC3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 9
- Number of somatic mutations (non-coding): 3
- Related genes and loops
- Related gene:
ENSG00000182670,
ENSG00000157542,
- Related loop:
chr21:34350000-34375000~~chr21:37200000-37225000,
chr21:36975000-37000000~~chr21:37200000-37225000,
chr21:37175000-37200000~~chr21:37625000-37650000,
chr21:37200000-37225000~~chr21:37425000-37450000,
chr21:37200000-37225000~~chr21:37475000-37500000,
chr21:37200000-37225000~~chr21:37525000-37550000,
chr21:37200000-37225000~~chr21:37550000-37575000,
chr21:37200000-37225000~~chr21:37625000-37650000,
chr21:37200000-37225000~~chr21:37650000-37675000,