Deatailed information for cohesin site CDBP00418772

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  • Basic information
  • CohesinDB ID: CDBP00418772
  • Locus: chr21-37206852-37210359
  • Data sourse: GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE121355, GSE103477, GSE111537, GSE131606, GSE25021, GSE165895, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE67783, GSE86191, GSE206145-NatGen2015, GSE120943, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, GSE62063, ENCSR000BMY, ENCSR000EHX, GSE55407, GSE38395, ENCSR167MTG, GSE131956, GSE110061, GSE129526, GSE111913, GSE155324, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE38411
  • Cell type: MDM, RH4, GM10847, GM2610, GM19240, HSPC, Liver, HuCC-T1, B-cell, RPE, GM2630, Fibroblast, Ishikawa, GM12890, hLCL, GM2255, BCBL-1, K-562, GM18486, DKO, HFFc6, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, RT-112, THP-1, GM19099, Macrophage, Ramos, GM12892, HCT-116, Hep-G2, GM19238, OCI-AML-3, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 20% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.522
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 90% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 32%, "5_TxWk": 28%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, MLL4, KDM3A, HDGF, THAP1, PAX5, TEAD1, LMO2, OCA2, HDAC8, E4F1, SOX5, E2F4, ZNF528, KMT2B, GATAD2A, ZNF263, POU5F1, TOP2A, CTBP1, DUX4, STAT1, SAP130, ERG, NFKB2, EZH1, SMARCA4, RFX1, RCOR1, NR2F6, NFRKB, CD74, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, DRAP1, MXI1, RELB, HCFC1R1, EP400, RUNX1, CEBPA, NKX2-2, HDAC1, IRF3, ZNF707, TET2, SP5, TRIM22, SMARCC1, PRDM10, SMARCB1, GMEB1, TERF1, ZNF331, EVI1, MBD1, STAT5A, ARID2, IKZF5, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, WT1, MEF2C, JUNB, NEUROD1, ZFP36, BATF, MAF1, SPIB, MED, ELF3, ARID4B, RXR, ZBTB26, NCOR1, HSF1, ILF3, FOSL1, XBP1, KDM4B, PBX2, HNRNPK, ATF3, THRB, ZFP64, RUNX3, ZNF532, CBFB, ZSCAN4, TP63, ZNF467, JMJD1C, ELF1, RBM39, KLF10, SMAD5, JUN, CTCF, L3MBTL4, MNT, DPF2, IRF4, PDX1, RBPJ, TFAP2C, MLX, MTA2, ZBTB48, NBN, ONECUT1, HOMEZ, NKX3-1, MIER3, TERF2, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, GRHL2, EBF3, SSRP1, SMARCA5, NFIL3, CC2D1A, THAP11, ZBTB24, SOX13, ZNF770, ARNT, BACH1, ZNF48, ZEB2, ETV6, PBX3, HMGXB4, TEAD3, U2AF1, TBX5, BCL11A, SP1, ATF7, ASH2L, SMC3, MLLT1, STAG1, TRP47, MTA3, EBF1, MEIS1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, ZIC2, TAL1, ZNF143, AGO2, TP53, ZNF334, NFKB1, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, RNF2, IKZF2, BRD4, JUND, CUX1, PGR, PATZ1, LEO1, UBTF, TFAP4, SIN3B, MXD4, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, TBP, ETS1, MYC, ARID1B, MCRS1, STAT3, IKZF1, INO80, SRSF3, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, ZNF384, NFYC, CREBBP, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, RBM22, MAFK, NR4A1, REST, BCOR, FOXP1, PPARG, TBL1X, GTF2B, TCF7, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, DMAP1, AHR, FOSL2, HMG20A, ZSCAN5C, HMGN3, MEIS2, RBFOX2, ZNF90, NFIC, MECOM, CDX2, KLF5, BCLAF1, TRIM28, RCOR2, MLL, TCF12, EP300, NUTM1, CREB3, SOX6, E2F1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, MLLT3, GATAD1, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, TFE3, HBP1, ZNF664, IRF1, SREBF1, ZGPAT, MRTFB, ZIM3, ATF1, PTBP1, SMC1A, MAFG, SIRT6, FIP1L1, ZFX, PCBP2, TWIST1, NSD2, IRF2, RUNX2, GATA4, PBX4, SUPT5H, FOS, TGIF2, MED1, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBTB33, CDK9, YY1, ZNF148, SP140, HIF1A, GATA1, HAND2, CEBPG, NCOA3, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, MYNN, NOTCH3, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): TTC3,DYRK1A,KCNJ6,HLCS
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 9
  • Related genes and loops
  • Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157540, ENSG00000157542,
  • Related loop: chr21:34350000-34375000~~chr21:37200000-37225000, chr21:36975000-37000000~~chr21:37200000-37225000, chr21:37200000-37225000~~chr21:37425000-37450000, chr21:37200000-37225000~~chr21:37475000-37500000, chr21:37200000-37225000~~chr21:37525000-37550000, chr21:37200000-37225000~~chr21:37550000-37575000, chr21:37200000-37225000~~chr21:37625000-37650000, chr21:37200000-37225000~~chr21:37650000-37675000,
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