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Basic information

CohesinDB ID: CDBP00418775

Locus: chr21-37220054-37222105

Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, Ramos, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 74% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.233

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "2_TssAFlnk": 28%, "5_TxWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, MORC2, PAX5, TEAD1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF507, ARID5B, E4F1, ZNF75A, SOX5, ZNF407, E2F4, DEK, RFX3, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, ZNF263, CTBP1, ZMYND11, ERF, DUX4, STAT1, SAP130, ERG, NFKB2, EZH1, SMARCA4, FOXK2, RCOR1, NR2F6, CD74, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, RELB, EP400, RUVBL2, RUNX1, CEBPA, NKX2-2, HDAC1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ELK1, ATF2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, ARID2, IKZF5, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, SS18, NFATC1, WT1, MEF2C, MPHOSPH8, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, PLAG1, KLF4, BCL11B, MED, ELF3, RBM14, ARID4B, RXR, ZBTB26, HSF1, NCOR1, ILF3, SMARCA2, XBP1, KDM4B, PBX2, THRB, ATF3, ZFP64, RUNX3, ZNF532, CBFB, DPF1, TP63, MITF, BACH2, JMJD1C, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, LMO1, MNT, RYBP, DPF2, IRF4, PDX1, MLX, TFAP2C, RBPJ, MTA2, ZBTB48, NONO, SRF, NBN, CHD4, ONECUT1, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, GRHL2, EBF3, KDM5A, SSRP1, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, LDB1, SOX13, AFF4, ZMIZ1, ZNF18, ARNT, BACH1, ZNF48, ZEB2, NFYA, ETV6, NCAPH2, PBX3, MAFB, HMGXB4, TEAD3, DIDO1, U2AF1, KLF9, USF1, BCL11A, SP1, ATF7, ASH2L, SMC3, MLLT1, STAG1, STAG2, SAFB, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, PCGF1, GATA3, TAL1, ZNF143, AGO2, TP53, ZNF334, NFKB1, PHF5A, BRD2, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, PGR, CBX5, SOX2, LEO1, RING1B, UBTF, TFAP4, SIN3B, CHD7, ZNF444, MXD4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, E2F6, TRIM24, RFX5, GTF2F1, POU2F2, ZSCAN5D, KDM4C, ASH1L, ZSCAN5A, ELK4, TBP, HOXC5, OGG1, ETS1, MYC, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, DNMT3B, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ETV5, BCL6, SIN3A, CREBBP, NFYC, RARA, ZNF384, TAF15, SMAD4, CDK8, CSNK2A1, ZEB1, SPDEF, ZMYM3, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, TBL1X, HDAC6, GTF2B, TCF7, FOXO3, RELA, TARDBP, CHAMP1, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NEUROG2, KDM5B, NR2F1, PKNOX1, MYOD1, AR, KMT2D, HEXIM1, AHR, DMAP1, MBD3, FOSL2, HMG20A, LCORL, E2F7, HMGN3, SUZ12, RBFOX2, LYL1, NFIC, CTCFL, MECOM, CDX2, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, BAF155, NUTM1, EP300, GATA6, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, MYCN, RUNX1T1, CDK7, ID3, MLLT3, GATAD1, GMEB2, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, TCF25, ZNF639, ZNF750, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, ZNF534, SMAD3, NMYC, TWIST1, IRF2, NOTCH1, BRD9, RUNX2, CDK6, GATA4, NRF1, CHD1, SUPT5H, FOS, TGIF2, MED1, KDM6B, MYB, CEBPD, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, BRCA1, SP140, HIF1A, OTX2, GATA1, HAND2, CEBPG, NCOA3, ZNF687, NFKBIZ, BHLHE40, TAF1, ZBTB40, ETS2, MYNN, NOTCH3, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): KCNJ6,HLCS,DYRK1A,VPS26C

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 88

Related genes and loops

Related gene: ENSG00000159267, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418775