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Basic information

CohesinDB ID: CDBP00418776

Locus: chr21-37223873-37226814

Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE50893, GSE73207

Cell type: RPE, GM2630, Fibroblast, HCT-116, GM2610, TF-1, RT-112, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: SA1,Rad21,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 52%, "5_TxWk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, XBP1, FOXA1, RBFOX2, LEO1, HDGF, ATF3, NFIC, ZFP64, RUNX3, PRDM1, ZNF532, MORC2, CBFB, MECOM, TP63, MAF, ELF1, TRIM28, RBM39, LMO2, ESR1, TP73, CTCF, TCF12, JUN, NUTM1, KLF1, LMO1, PAX8, E2F6, FOXA3, EED, ZSCAN5D, MYCN, ZNF263, TOP2A, RUNX1T1, POU5F1, ZBTB48, STAT1, ZNF205, ERG2, ERG, OGG1, MYC, SMARCA4, FOXP2, GRHL3, GABPA, STAT3, XRCC5, DNMT3B, STAT5B, KMT2A, SPI1, HDAC2, GATA2, MXD3, FLI1, HEXIM1-CDK9, NFIL3, RUNX1, CIITA, CEBPA, ZFX, ERG3, RARA, NOTCH1, TAF15, GATA4, ARNT, NFIB, ZNF48, SUPT5H, HMGXB4, FOS, TEAD3, TERF1, MYB, SCRT2, SMAD1, ZNF3, EVI1, STAT5A, RBM22, BCL11A, NR4A1, ARID2, REST, TCF3, MBD2, AATF, SMC3, STAG1, MLLT1, TRP47, FOXA2, MEIS1, PAF1, WT1, ZBTB33, MPHOSPH8, KDM1A, YY1, RELA, NEUROD1, JUNB, SP140, GATA3, TAL1, MAX, MAF1, GATA1, AGO2, PLAG1, CBX2, BCL11B, ZNF141, NR2F1, KDM5B, ZNF334, PHOX2B, TBX21, AR, ZBTB16, YAP1, HEXIM1, ZBTB26, HSF1, MYNN, BRD4, SCRT1, NOTCH3, MAZ, AHR

Target gene symbol (double-evidenced CRMs): VPS26C,DYRK1A,HLCS,KCNJ6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 105

Number of somatic mutations (non-coding): 40

Related genes and loops

Related gene: ENSG00000159267, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418776