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Basic information

CohesinDB ID: CDBP00418781

Locus: chr21-37237790-37238115

Data sourse: ENCSR230ZWH, GSE98367, GSE138405, ENCSR000BMY, ENCSR000EDE, ENCSR000ECS, ENCSR917QNE

Cell type: Hela-Kyoto, GM12878, HeLa-S3, Liver, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SMC1,SMC3ac,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 48%, "5_TxWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MEIS2, XBP1, FOXA1, LEO1, PBX2, ATF3, THAP1, ZNF532, MECOM, MITF, TRIM28, ZNF121, ZNF573, ESR1, OCA2, CTCF, NUTM1, TFAP2C, RBPJ, POU2F2, CHD8, ZSCAN5D, ZNF263, MYCN, RUNX1T1, CDK7, POU5F1, ERF, ZBTB48, ZSCAN5A, STAT1, SAP130, DDX5, TBP, ERG, OGG1, ETS1, MYC, SMARCA4, EOMES, RAD21, GRHL3, GABPA, STAT3, XRCC5, DNMT3B, NR2F6, HNRNPH1, VDR, TERF2, CEBPB, EZH2, SPI1, ZNF257, GATA2, FLI1, NFIL3, ETV5, RUNX1, SMC1A, MAFG, SIRT6, ZFX, TET2, ERG3, ZNF770, CREBBP, ZNF384, ARNT, PRDM9, SMAD4, FOXM1, SUPT5H, CDK8, MED1, TEAD3, SCRT2, ZNF3, C11orf30, EVI1, RBM22, MAFK, BCL11A, ARID2, REST, ASH2L, FOXP1, AATF, SMC3, STAG1, TRP47, ZNF283, ZNF316, PAF1, WT1, MAFF, ZNF574, ZBTB33, HOXB13, YY1, RELA, SP140, ZIC2, HIF1A, OTX2, GATA3, TAL1, MAX, ZNF143, AGO2, GATA1, CBX2, NR2F1, TP53, ZNF334, PHOX2B, TBX21, ARID4B, AR, RXR, HEXIM1, MYNN, NCOR1, HSF1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): DYRK1A,KCNJ6,VPS26C,HLCS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000159267, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418781