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Basic information

CohesinDB ID: CDBP00418786

Locus: chr21-37248968-37249483

Data sourse: GSE93080, GSE62063

Cell type: GM12878, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: NIPBL,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 57%, "15_Quies": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, SOX2, XBP1, FOXA1, LEO1, HNRNPK, HDGF, NFIC, RUNX3, CHD7, PRDM1, ZNF532, PAX5, TP63, MAF, TEAD1, RBM39, ESR1, MLL, CTCF, TCF12, BAF155, NUTM1, TEAD4, TFAP2C, POU2F2, CHD8, BRD1, NANOG, POU5F1, MYCN, TOP2A, MTA2, ZBTB48, ZSCAN5A, STAT1, DUX4, ZNF563, SRF, ERG, MYC, SMARCA4, RAD21, GRHL3, NKX3-1, ZNF667, NR3C1, STAT5B, KMT2A, CREB1, SPI1, ZNF664, GATA2, SIX2, FLI1, RELB, RUNX1, SMC1A, NKX2-2, SIN3A, ZFX, ZNF770, ERG3, PRDM10, ZNF384, RUNX2, ARNT, ATF2, ZEB2, MED1, TEAD3, MYB, PIAS1, C11orf30, STAT5A, RBM22, USF1, BCL11A, MAFK, ZBTB7A, ARID1A, RBM25, ASH2L, PHIP, TCF3, FOXP1, PRDM6, SMC3, STAG1, MEF2B, FOXA2, EBF1, PAF1, E2F8, WT1, TCF7, HOXB13, KDM1A, YY1, RELA, JUNB, SP140, HIF1A, BATF, TAL1, MAX, GATA1, TLE3, BCL11B, PKNOX1, MYOD1, PHOX2B, AR, NOTCH3, BRD4, CLOCK, MAZ, ZNF316

Target gene symbol (double-evidenced CRMs): VPS26C,KCNJ6,HLCS,DYRK1A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000157538, ENSG00000157540, ENSG00000157542,

eachgene

Deatailed information for cohesin site CDBP00418786