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Basic information

CohesinDB ID: CDBP00418788

Locus: chr21-37254108-37254748

Data sourse: ENCSR000BTU, GSE67783, GSE86191, GSE206145-NatGen2015, ENCSR153HNT

Cell type: Fibroblast, HCT-116, Ishikawa, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 60%, "15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, E2F7, ZSCAN5C, SOX2, MEIS2, FOXA1, PBX2, HDGF, ATF3, ZFP64, ZBTB44, PRDM1, IKZF3, ZNF532, ATF4, ZNF273, MECOM, SMARCE1, ZNF189, JMJD1C, ZNF629, TEAD1, TRIM28, NFE2L2, OCA2, TP73, CTCF, JUN, NUTM1, MNT, DPF2, PRDM4, TRIM24, TEAD4, KMT2B, GATAD2A, TFAP2C, GLIS1, CHD8, POU5F1, ZNF263, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, SRF, DDX5, ARID3A, ERG, ZNF341, MYC, EZH1, SMARCA4, ARID1B, RAD21, RXRA, FOXK2, STAT3, NKX3-1, RCOR1, NFE2, NR3C1, ZNF750, CEBPB, KMT2A, CREB1, EZH2, FEZF1, ZKSCAN5, SPI1, GATA2, INTS13, SIX2, FLI1, MXI1, SMARCA5, MRTFB, ZNF554, RUNX1, SMC1A, CEBPA, HDAC1, SIN3A, ZFX, ZNF770, TRIM22, PRDM10, CREBBP, ZNF384, ZNF35, GATA4, OSR2, ZNF184, ZEB2, ZNF10, FOS, CDK8, SUPT5H, MED1, CEBPD, MYB, SMAD1, C11orf30, L3MBTL2, EVI1, RBM22, MAFK, BCL11A, GSPT2, HNF4A, ZBTB7A, PHIP, TCF3, PRDM6, SMC3, STAG1, MLLT1, STAG2, SKI, PPARG, FOXA2, MEIS1, ZNF600, ZNF692, ZSCAN16, WT1, ZNF574, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, NEUROD1, SP140, MGA, MAX, ZNF143, CEBPG, SP7, NCOA3, NR2F2, TP53, NFKB1, ELF3, BHLHE40, AR, TAF1, ZBTB40, RXR, ZNF324, EGR1, BRD4, JUND, SCRT1, CUX1, MAZ, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): VPS26C,HLCS,KCNJ6,KCNJ15,TTC3,DYRK1A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159267, ENSG00000182670, ENSG00000157538, ENSG00000157540, ENSG00000157542, ENSG00000157551,

eachgene

Deatailed information for cohesin site CDBP00418788